The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153
Open accessAbstract
In the present study, we show that Fas receptor ligation or cellular treatment with synthetic C6-ceramide results in activation or phosphorylation, respectively, of the small G-protein Rac1, Jun N-terminal kinase (JNK)/p38 kinases (p38-K), and the transcription factor GADD153. A signaling cascade from the Fas receptor via ceramide, Ras, Rac1, and JNK/p38-K to GADD153 is demonstrated employing transfection of transdominant inhibitory N17Ras, N17Rac1, c-Jun, or treatment with a specific p38-K inhibitor. The critical function of this signaling cascade is indicated by prevention of Fas- or C6-ceramide-induced apoptosis after inhibition of Ras, Rac1, or JNK/p38-K.
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Cites
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Cited by
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
WIDMANN, C., GIBSON, S., JARPE, M. B., & JOHNSON, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,729
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Requirement for ERK Activation in Cisplatin-induced Apoptosis
Wang, X., Martindale, J. L., & Holbrook, N. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004583200 · Cited by 675
Radiation and ceramide-induced apoptosis
Kolesnick, R., & Fuks, Z. (2003) · Oncogene · doi:10.1038/sj.onc.1206702 · Cited by 506
Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs
Gulbins, E., Palmada, M., Reichel, M., Lüth, A., Böhmer, C., Amato, D., Müller, C. P., Tischbirek, C. H., Groemer, T. W., Tabatabai, G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3214 · Cited by 384
Self-citation
Metadata
- Authors
- Brenner, B., Koppenhoefer, U., Weinstock, C., Linderkamp, O., Lang, F., & Gulbins, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 272
- Issue
- 35
- Pages
- 22173-22181
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1969436183
- Cited by
- 297
- References
- 75
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153. https://app.cochat.ai/papers/10.1074/jbc.272.35.22173
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- Brenner, B., Koppenhoefer, U., Weinstock, C., Linderkamp, O., Lang, F., & Gulbins, E. (1997). Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.35.22173
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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