The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.
Open accessAbstract
Naive CD4+ T cells can differentiate into cells predominantly involved in humoral immunity, known as T helper type 2 cells (Th2), or cells involved in cell-mediated immunity, known as Th1 cells. In this report, we show that priming of CD4+ T cells bearing a transgene-encoded T cell receptor can lead to differentiation into Th1-like cells producing abundant interferon gamma when the cells are exposed to high antigen doses, while low doses of the same peptide induce cells with the same T cell receptor to differentiate into Th2-like cells producing abundant interleukin 4. Thus antigen dose is one factor that can control the differentiation fate of a naive CD4+ T cell.
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Cites
Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954
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Metadata
- Authors
- Constant, S., Pfeiffer, C., Woodard, A., Pasqualini, T., & Bottomly, K.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-11-01
- Volume
- 182
- Issue
- 5
- Pages
- 1591-1596
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2100699905
- Cited by
- 677
- References
- 1
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Constant, S., Pfeiffer, C., Woodard, A., Pasqualini, T., & Bottomly, K. (1995). Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.182.5.1591
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
