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Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.
Open accessAbstract
We used the simian immunodeficiency virus (SIV)/rhesus macaque model to study events that underlie sexual transmission of human immunodeficiency virus type 1 (HIV-1). Four female rhesus macaques were inoculated intravaginally with SIVmac251, and then killed 2, 5, 7, and 9 d later. A technique that detected polymerase chain reaction-amplified SIV in situ showed that the first cellular targets for SIV were in the lamina propria of the cervicovaginal mucosa, immediately subjacent to the epithelium. Phenotypic and localization studies demonstrated that many of the infected cells were likely to be dendritic cells. Within 2 d of inoculation, infected cells were identified in the paracortex and subcapsular sinus of the draining internal iliac lymph nodes. Subsequently, systemic dissemination of SIV was rapid, since culturable virus was detectable in the blood by day 5. From these results, we present a model for mucosal transmission of SIV and HIV-1.
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Citations
Cited by
Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells
Zhang, Z.-Q., Schuler, T., Zupancic, M., Wietgrefe, S., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., et al. (1999) · Science · doi:10.1126/science.286.5443.1353 · Cited by 874
Self-citationAcute Human Immunodeficiency Virus Type 1 Infection
Kahn, J. O., & Walker, B. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807023390107 · Cited by 733
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
Turville, S. G., Santos, J. J., Frank, I., Cameron, P. U., Wilkinson, J., Miranda-Saksena, M., Dable, J., Stössel, H., Romani, N., Piatak, M., et al. (2004) · Blood · doi:10.1182/blood-2003-09-3129 · Cited by 397
Zaitseva, M., Blauvelt, A., Lee, S., Lapham, C. K., Kiaus-Kovrun, V., Mostowski, H., Manischewitz, J., & Golding, H. (1997) · Nature Medicine · doi:10.1038/nm1297-1369 · Cited by 389
Pudney, J., Quayle, A. J., & Anderson, D. J. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.043133 · Cited by 373
Metadata
- Authors
- Spira, A. I., Marx, P. A., Patterson, B. K., Mahoney, J., Koup, R. A., Wolinsky, S. M., & Ho, D. D.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-01-01
- Volume
- 183
- Issue
- 1
- Pages
- 215-225
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2116720206
- Cited by
- 692
- References
- 0
- FWCI
- 17.35
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. https://app.cochat.ai/papers/10.1084/jem.183.1.215
- The paper
- Spira, A. I., Marx, P. A., Patterson, B. K., Mahoney, J., Koup, R. A., Wolinsky, S. M., & Ho, D. D. (1996). Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. The Journal of experimental medicine. https://doi.org/10.1084/jem.183.1.215
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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