The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells
Abstract
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus–type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4 + T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1–infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.
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Citations
Cites
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Cited by
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication
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Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells
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Metadata
- Authors
- Zhang, Z.-Q., Schuler, T., Zupancic, M., Wietgrefe, S., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., Veazey, R. S., Notermans, D., Little, S., Danner, S. A., Richman, D. D., Havlir, D., Wong, J., Jordan, H. L., Schacker, T. W., Racz, P., Tenner-Racz, K., Letvin, N. L., Wolinsky, S., & Haase, A. T.
- Venue
- Science
- Published
- 1999-11-12
- Volume
- 286
- Issue
- 5443
- Pages
- 1353-1357
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2162703129
- Cited by
- 874
- References
- 41
- FWCI
- 16.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, Z.-Q., Schuler, T., Zupancic, M., Wietgrefe, S., Staskus, K. A., Reimann, K. A., Reinhart, T. A., Rogan, M., Cavert, W., Miller, C. J., Veazey, R. S., Notermans, D., Little, S., Danner, S. A., Richman, D. D., Havlir, D., Wong, J., Jordan, H. L., Schacker, T. W., . . . Haase, A. T. (1999). Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells. Science. https://doi.org/10.1126/science.286.5443.1353
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
