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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.
Open accessAbstract
In Hodgkin's disease (HD), the Hodgkin and Reed-Sternberg (HRS) cells represent only a minute population in the diseased tissue. The investigation of lineage derivation and clonal origin of these cells has yielded conflicting results. We have analyzed HRS cells micromanipulated from infiltrated tissue sections of 10 primary HD patients for rearranged V genes, extending a previous study. Clonally related rearrangements were found in nine cases, indicating that HRS cells represent a dominant clone of B lineage-derived cells in at least a large fraction of cases of HD. Rearranged VH genes from HRS cells carried a high load of somatic mutation, indicating that HRS cells are derived from germinal center (GC) cells or their progeny. Stop codons in some in-frame V gene rearrangements suggest that the HRS cell precursors reside inside GCs, have acquired crippling mutations that prevent antigenic selection, but escape apoptosis through some transforming event.
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Citations
Cited by
Mechanisms of B-cell lymphoma pathogenesis
Küppers, R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1589 · Cited by 965
Self-citationThe biology of Hodgkin's lymphoma
Küppers, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2542 · Cited by 688
Self-citationGoossens, T., Klein, U., & Küppers, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2463 · Cited by 342
Self-citationLiso, A. (2006) · Blood · doi:10.1182/blood-2005-10-3949 · Cited by 84
Metadata
- Authors
- Kanzler, H., Küppers, R., Hansmann, M. L., & Rajewsky, K.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1996-10-01
- Volume
- 184
- Issue
- 4
- Pages
- 1495-1505
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1974010997
- Cited by
- 742
- References
- 0
- FWCI
- 21.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. https://app.cochat.ai/papers/10.1084/jem.184.4.1495
- The paper
- Kanzler, H., Küppers, R., Hansmann, M. L., & Rajewsky, K. (1996). Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.184.4.1495
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
