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Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma
Open accessAbstract
We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchial eosinophils and striking pathologic changes including the expansion of bronchusassociated lymphoid tissue (BALT), goblet cell hyperplasia, epithelial hypertrophy, and focal collagen deposition. These changes were also accompanied by eosinophil infiltration of the airway lumen. In addition, transgenic animals displayed airway hyperresponsiveness to methacholine in the absence of aerosolized antigen challenge. These findings demonstrate that lung-specific IL-5 expression can induce pathologic changes characteristic of asthma and may provide useful models to evaluate the efficacy of potential respiratory disease therapies or pharmaceuticals.
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Citations
Cited by
Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356
IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS
Wills-Karp, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.255 · Cited by 1,020
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Zhou, B., Comeau, M. R., Smedt, T. D., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D., Aye, T., Campbell, D. J., & Ziegler, S. F. (2005) · Nature Immunology · doi:10.1038/ni1247 · Cited by 819
Temann, U.-A., Geba, G. P., Rankin, J. A., & Flavell, R. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1307 · Cited by 452
A role for eosinophils in airway remodelling in asthma
Kay, A. B., Phipps, S., & Robinson, D. S. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.07.006 · Cited by 320
Metadata
- Authors
- Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D., & Lee, N. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-06-16
- Volume
- 185
- Issue
- 12
- Pages
- 2143-2156
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129886691
- Cited by
- 518
- References
- 0
- FWCI
- 18.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma. https://app.cochat.ai/papers/10.1084/jem.185.12.2143
- The paper
- Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., Leikauf, G. D., & Lee, N. A. (1997). Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.185.12.2143
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
