The eosinophil

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A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

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Mast-Cell Infiltration of Airway Smooth Muscle in Asthma

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The Molecular Biology of Leukocyte Chemoattractant Receptors

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Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

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Interleukin-5, eosinophils, and disease

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Recombinant human interleukin 5 is a selective activator of human eosinophil function.

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Eosinophilic gastrointestinal disorders (EGID)

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Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma

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A Critical Role for Eosinophils in Allergic Airways Remodeling

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Eosinophilia

Rothenberg, M. E. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805283382206 · Cited by 837 · see citing works

The Eosinophilic Leukocyte: Structure and Function

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Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

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Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation

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Regulation of B lymphocyte and macrophage development by graded expression of PU.1

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Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

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Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

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Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

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An etiological role for aeroallergens and eosinophils in experimental esophagitis

Mishra, A., Hogan, S. P., Brandt, E. B., & Rothenberg, M. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10224 · Cited by 626 · see citing works

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

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Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

Yu, C., Cantor, A. B., Yang, H., Browne, C., Wells, R. A., Fujiwara, Y., & Orkin, S. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020656 · Cited by 600 · cited 3× · see citing works

Cytotoxic Properties of the Eosinophil Major Basic Protein

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IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

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Eosinophilia in transgenic mice expressing interleukin 5.

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Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

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An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

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The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness

Gonzalo, J.-Á., Lloyd, C. M., Wen, D., Albar, J. P., Wells, T. N. C., Proudfoot, A. E. I., Martínez‐A, C., Dorf, M. E., Bjerke, T., Coyle, A. J., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.157 · Cited by 534 · see citing works

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

Rothenberg, M. E., MacLean, J. A., Pearlman, E. M., Luster, A. D., & Leder, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.785 · Cited by 524 · see citing works

Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma

Lee, J. J., McGarry, M. P., Farmer, S. C., Denzler, K. L., Larson, K. A., Carrigan, P. E., Brenneise, I. E., Horton, M. A., Haczku, A., Gelfand, E. W., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.12.2143 · Cited by 517 · see citing works

Effect of SCH55700, a Humanized Anti-Human Interleukin-5 Antibody, in Severe Persistent Asthma: A Pilot Study

KIPS, J. C., O'Connor, B. J., Langley, S. J., Woodcock, A. A., Kerstjens, H. A. M., Postma, D. S., Danzig, M., Cuss, F. M., & PAUWELS, R. A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200206-525oc · Cited by 494 · see citing works

Postnatal mammary gland development requires macrophages and eosinophils

Gouon–Evans, V., Rothenberg, M. E., & Pollard, J. W. (2000) · Development · doi:10.1242/dev.127.11.2269 · Cited by 463 · see citing works

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

Nerlov, C., & Graf, T. (1998) · Genes & Development · doi:10.1101/gad.12.15.2403 · Cited by 449 · see citing works

Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors.

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Type 2 Immunity Reflects Orchestrated Recruitment of Cells Committed to IL-4 Production

Voehringer, D., Shinkai, K., & Locksley, R. M. (2004) · Immunity · doi:10.1016/s1074-7613(04)00026-3 · Cited by 425 · see citing works

Mechanism of membrane damage mediated by human eosinophil cationic protein

Young, J. D., Peterson, C. G. B., Venge, P., & Cohn, Z. A. (1986) · Nature · doi:10.1038/321613a0 · Cited by 408 · see citing works

Fundamental signals that regulate eosinophil homing to the gastrointestinal tract

Mishra, A., Hogan, S. P., Lee, J. J., Foster, P. S., & Rothenberg, M. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6560 · Cited by 399 · see citing works

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

Humbles, A. A., Lu, B., Friend, D. S., Okinaga, S., Lora, J. M., Al-Garawi, A. A., Martin, T. R., Gerard, N. P., & Gerard, C. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261462598 · Cited by 390 · see citing works

Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism1 1The authors thank Andrea Lippelman for editorial assistance; Drs. Fred Finkelman, Eric Brandt, Simon Hogan, and Paul Foster for helpful discussions and/or reagents; Drs. James and Nancy Lee (Mayo Clinic, Scottsdale, AZ) for the generous supply of anti-MBP; Dr. Debra Donaldson (Wyeth Research, Cambridge, MA) for the generous supply of recombinant IL-13; and Klaus Matthaei (Australian National University, Canberra, Australia) for the original supply of the IL-5 (Balb/c) gene targeted mice.

Mishra, A., & Rothenberg, M. E. (2003) · Gastroenterology · doi:10.1016/j.gastro.2003.07.007 · Cited by 375 · see citing works

Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

Jacoby, D. B., Gleich, G. J., & Fryer, A. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116331 · Cited by 342 · see citing works

Chemokines in asthma: Cooperative interaction between chemokines and IL-13

Rosenwasser, L. J., Zimmermann, N., Hershey, G. K. K., Foster, P. S., & Rothenberg, M. E. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.139 · Cited by 330 · see citing works

Lymph node trafficking and antigen presentation by endobronchial eosinophils

Shi, H., Humbles, A. A., Gerard, C. J., Jin, Z., & Weller, P. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8945 · Cited by 326 · see citing works

Effects of an Antibody to Interleukin-5 in a Monkey Model of Asthma

Mauser, P. J., Pitman, A., Fernandez, X., et al. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633694 · Cited by 325 · see citing works

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

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Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis

Nutku, E., Aizawa, H., Hudson, S. A., & Bochner, B. S. (2003) · Blood · doi:10.1182/blood-2002-10-3058 · Cited by 304 · see citing works

Treatment of hypereosinophilic syndrome with imatinib mesilate

Gleich, G. J., Leiferman, K. M., Pardanani, A. D., Tefferi, A., & Butterfield, J. H. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08505-7 · Cited by 303 · see citing works

A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation

Hogan, S. P., Mishra, A., Brandt, E. B., Royalty, M. P., Pope, S. M., Zimmermann, N., Foster, P. S., & Rothenberg, M. E. (2001) · Nature Immunology · doi:10.1038/86365 · Cited by 302 · see citing works

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

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IL‐5‐induced airway eosinophilia – the key to asthma?

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Eosinophil cationic protein (ECP): molecular and biological properties and the use of ECP as a marker of eosinophil activation in disease

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Eotaxin is required for the baseline level of tissue eosinophils

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Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.

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Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens

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Eosinophils Are a Major Source of Nitric Oxide-Derived Oxidants in Severe Asthma: Characterization of Pathways Available to Eosinophils for Generating Reactive Nitrogen Species

MacPherson, J. C., COMHAIR, S. A. A., ERZURUM, S. C., Klein, D. F., Lipscomb, M. F., Kavuru, M. S., Samoszuk, M. K., & Hazen, S. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5763 · Cited by 280 · see citing works

α4Integrins as Therapeutic Targets in Autoimmune Disease

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A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils

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Eosinophil peroxidase nitrates protein tyrosyl residues

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Intrinsic Defect in T Cell Production of Interleukin (IL)-13 in the Absence of Both IL-5 and Eotaxin Precludes the Development of Eosinophilia and Airways Hyperreactivity in Experimental Asthma

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Antiinterleukin-5 Antibody Prevents Airway Hyperresponsiveness in a Murine Model of Airway Sensitization

Hamelmann, E. H., Oshiba, A., Loader, J., et al. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.3.9117011 · Cited by 262 · see citing works

Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates

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Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

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Allergic Eosinophil-rich Inflammation Develops in Lungs and Airways of B Cell–deficient Mice

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Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages As Well As Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers

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The Eotaxin Chemokines and CCR3 Are Fundamental Regulators of Allergen-Induced Pulmonary Eosinophilia

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Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein.

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Eotaxin and eosinophil recruitment: implications for human disease

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Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies

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The role of adhesion molecules in human eosinophil and basophil recruitment

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Eosinophils Promote Allergic Disease of the Lung by Regulating CD4+ Th2 Lymphocyte Function

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Elemental signals regulating eosinophil accumulation in the lung

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Essential and Instructive Roles of GATA Factors in Eosinophil Development

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Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development

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The Role of Eosinophils in Parasitic Helminth Infections: Insights from Genetically Modified Mice

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The effects of glucocorticoids on human eosinophils

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The trials and tribulations of IL-5, eosinophils, and allergic asthma

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Cutting Edge: Human Eosinophils Regulate T Cell Subset Selection through Indoleamine 2,3-Dioxygenase

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Helper T cells regulate type-2 innate immunity in vivo

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