Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling
Cope, Andrew P., Liblau, Roland S., Yang, Xiao-Dong, Congia, Mauro, Laudanna, Carlo, Schreiber, Robert D., Probert, Lesley, Kollias, George, McDevitt, Hugh O.·1997·The Journal of Experimental Medicine
Cited by (287)
Items 201–287 of 287
- Regulation of myeloid cell function and major histocompatibility complex class II expression by tumor necrosis factorRuediger B. Müeller, Alla Skapenko, Mathias Grünke, Jörg Wendler, Bruno Stuhlmüller, Joachim Robert Kalden, Hendrik Schulze‐Koops · 2005 · Arthritis & Rheumatism
- TNF-α and IFN-γ gene variation and genetic susceptibility to type 1 diabetes and its microangiopathic complicationsJavad Tavakkoly‐Bazzaz, Mahsa Mohammad Amoli, Zahra Taheri, Bagher A. Larijani, Vera Pravica, Ian V. Hutchinson · 2014 · Journal of Diabetes & Metabolic Disorders
- Glial expression of tumor necrosis factor in transgenic animals: How do these models reflect the “normal situation”?Lesley Probert, Katerina Akassoglou · 2001 · Glia
- Role of TNFR1 in the innate airway hyperresponsiveness of obese miceMing Zhu, Alison Suzanne Williams, Lucas Chen, Allison Patricia Wurmbrand, Erin S. Williams, Stephanie Ann Shore · 2012 · Journal of Applied Physiology
- Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cellsBi‐Feng Qian, Susan L. Tonkonogy, Ryan Balfour Sartor · 2008 · Inflammatory Bowel Diseases
- Chronic TNF-α exposure impairs TCR-signaling via TNF-RII but not TNF-RIRosa Maria Aspalter, Hermann Maximilian Wolf, Martha Marianne Eibl · 2005 · Cellular Immunology
- Blockade of gamma interferon might be beneficial in MSLawrence Steinman · 2001 · Multiple Sclerosis Journal
- Effect of genetic modificationsby selection for immunological toleranceon fungus infection in miceAntonio Carlos da Silva, Leila Maria Lopes-Bezerra, Thula Santos Aguiar, Daniel Tavares, Luiza M. M. Araujo, Carla Eponina Carvalho-Pinto, Orlando Garcia Ribeiro · 2001 · Microbes and Infection
- Tumor necrosis factor-alpha as a potential therapeutic target in idiopathic inflammatory myopathiesJoerg‐Patrick Stübgen · 2011 · Journal of Neurology
- Evidence for additionally increased apoptosis in the peripheral blood mononuclear cells of major depressive patients with a high risk for suicideAmidfar, Meysam, Kim, Yong‐Ku, Scaini, Giselli, Quevedo, João · 2018 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- TNFRI is a positive T‐cell costimulatory molecule important for the timing of cytokine responsesMaria Evangelidou, Vivian Tseveleki, Sotirios‐Spyridon M. Vamvakas, Lesley Probert · 2010 · Immunology and Cell Biology
- Use of a microgravity organ culture dish system to demonstrate the signal dampening effects of modeled microgravity during T cell developmentChris C. Woods, Krista E. Banks, Ty W. Lebsack, Todd C. White, Grant Allan Anderson, Taber MacCallum, Raphael Gruener, Dominick DeLuca · 2004 · Developmental & Comparative Immunology
- TNFR2 signaling modulates immunity after allogeneic hematopoietic cell transplantationAntonella Mancusi, Maite Álvarez, Sara Piccinelli, Andrea Velardi, Antonio Pierini · 2019 · Cytokine & Growth Factor Reviews
- Involvement of the TNF-α/TGF-β/IDO axis in IVIg-induced immune toleranceLionel Loubaki, Dominique Chabot, Renée Bazin · 2014 · Cytokine
- Regulation of Virally Induced Autoimmunity and Immunopathology: Contribution of LCMV Transgenic Models to Understanding Autoimmune Insulin-Dependent Diabetes MellitusMatthias G. von Herrath · 2002 · Current topics in microbiology and immunology
- Transgenic Animal Models for Type 1 Diabetes: Linking a Tetracycline-Inducible Promoter with a Virus-Inducible Mouse ModelUrs Christen, Matthias G. von Herrath · 2002 · Transgenic Research
- Persistent TNF‐α exposure impairs store operated calcium influx in CD4+ T lymphocytesLeigh D Church, John E. Goodall, David A. Rider, PAUL A. BACON, Stephen P. Young · 2005 · FEBS Letters
- A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritisAnn Wendy Morgan, G Hale, P Rebello, Stephen John Richards, H.C. Gooi, Herman Waldmann, Paul Emery, John Dudley Isaacs · 2008 · QJM
- Genetics of tumour necrosis factor (TNF) in autoimmune liver diseases: red hot or red herring?Anthony Gerard Wilson · 1999 · Journal of Hepatology
- Interleukin 10 is not essential for survival or for modulating T-cell function after injuryEamon K. Kavanagh, Malcolm Kell, Andreas Göebel, Christopher C. Soberg, John A. Mannick, James Arthur Lederer · 1999 · Surgery
- Differences in the Immune Response During the Acute Phase of E-55+ Murine Leukemia Virus Infection in Progressor BALB and Long Term Nonprogressor C57BL MiceVily Panoutsakopoulou, Christopher Scott Little, Thomas G. Sieck, Elizabeth P. Blankenhorn, Kenneth J. Blank · 1998 · The Journal of Immunology
- Secondary Central Nervous System Demyelinating Disorders in the Elderly: A Narrative ReviewChristos Bakirtzis, Maria Lima, Sotiria Stavropoulou De Lorenzo, Artemios Artemiadis, Paschalis Theotokis, Evangelia Kesidou, Natalia Konstantinidou, Styliani-Aggeliki Sintila, Marina Kleopatra Boziki, Dimitrios Parissis et al. · 2023 · Healthcare
- The Expression of Cytokine Genes in the Peritoneal Macrophages and Splenic CD4- and CD8-Positive Lymphocytes of the Nonobese Diabetic MiceNik-Soriani Yaacob, Mohd-Arifin Kaderi, Mohd Nor Norazmi · 2004 · Journal of Clinical Immunology
- Secondary immune deficiencies associated with biological therapeuticsSang Hyuck Lee, Parekha Yedla, Arthur Kavanaugh · 2003 · Current Allergy and Asthma Reports
- A review of the use of biological agents for chronic inflammatory demyelinating polyradiculoneuropathyJoerg‐Patrick Stübgen · 2013 · Journal of the Neurological Sciences
- Cytokines and immunopathogenesis of intraocular posterior segment inflammationAndrew D. Dick, D. A. Carter · 2003 · Ocular Immunology and Inflammation
- CD4+T-cell subsets in rheumatoid arthritisFrédérique Ponchel, Edward M J Vital, Sarah R. Kingsbury, Yasser Mohamed El-Sherbiny · 2012 · International Journal of Clinical Rheumatology
- Chronic Inflammatory Demyelinating Polyneuropathy Following Anti-TNF-α Therapy With Infliximab for Crohn's DiseaseAmir Y. Kamel, Orestes Concepcion, Alexander Schlachterman, Sarah Camille Glover, Christopher Y. Forsmark · 2016 · ACG Case Reports Journal
- Neutralization Versus Reinforcement of Proinflammatory Cytokines to Arrest Autoimmunity in Type 1 DiabetesAyelet Kaminitz, Shifra Ash, Nadir Askenasy · 2016 · Clinical Reviews in Allergy & Immunology
- TNF-α mediated modulation of T cell development and exacerbation of in vitro T1DM in fetal thymus organ cultureAaron J. Middlebrook, Ty W. Lebsack, Dominick DeLuca · 2007 · Journal of Autoimmunity
- Infliximab Does Not Lead to Reduction in the Interferon-gamma and Lymphoproliferative Responses of Patients with Moderate to Severe PsoriasisL Ortigosa, Larissa K. A. da Silva, A Duarte, Maria Denise Fonseca Takahashi, Gil Benard · 2014 · Acta Dermato Venereologica
- The development of chronic inflammatory demyelinating polyneuropathy during adalimumab treatment in a patient with psoriasis vulgarisMomoko Nakao, Yoshihide Asano, Kouki Nakamura, Rino Shida, Takehiro Takahashi, Ayumi Yoshizaki, Aya Mitsui, Sayaka Shibata, Mayuko Araki, Rei Watanabe et al. · 2016 · European Journal of Dermatology
- TNF-α Receptor 1 (p55) on Islets Is Necessary for the Expression of LIGHT on Diabetogenic T CellsSyamasundar V. Pakala, Alex Ilic, LiePing Chen, Nora Sarvetnick · 2001 · Clinical Immunology
- Recent advances in immunology in multiple sclerosisRoland Liblau, Bertrand Fontaine · 1998 · Current Opinion in Neurology
- Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitisEmma C. Erlich, Quazim A. Alayo, Ayoung Kim, Jichang Han, Rachel L. Mintz, Christopher G. Huckstep, Heather S. Ruiz, Rachael L. Field, Taylor J Dunning, Leila S. Saleh et al. · 2025 · Nature Immunology
- TNF-α inhibits the CD3-mediated upregulation of voltage-gated K+ channel (Kv1.3) in human T cellsBo Pang, Haifeng Zheng, Dong Hoon Shin, Kyeong Cheon Jung, Jae Hong Ko, Kyung‐Yul Lee, Tong Mook Kang, Sung Joon Kim · 2009 · Biochemical and Biophysical Research Communications
- TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren’s syndrome patientsAna Lilia Fletes-Rayas, Claudia Azucena Palafox‐Sánchez, José Francisco Muñóz-Valle, Gerardo Orozco‐Barocio, Rosa Elena Navarro-Hernández, Edith Oregon‐Romero · 2016 · Genetics and Molecular Research
- No signs of immunoactivation in the cerebrospinal fluid during treatment with infliximabMagnus Andersson, Elisabet Svenungsson, Mohsen Khademi, Jon Lampa, Lou Brundin, Erik Wallström · 2006 · Annals of the Rheumatic Diseases
- CHARACTERIZATION OF GRAFT-VERSUS-HOST DISEASE IN SCID MICE AND PREVENTION BY PHYSICOCHEMICAL STRESSORSXiaofang Sheng-Tanner, Colin McKerlie, David Spaner · 2000 · Transplantation
- In vitrodifferentiation of peripheral blood T cells towards a type 2 phenotype is impaired in rheumatoid arthritis (RA)S Asselin, Hélène Conjeaud, DIDIER FRADELIZI, Maxime Bréban · 1998 · Clinical & Experimental Immunology
- Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signalingHella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Éva M. Szegő, Wulf Tonnus, Stefan Winkler, Claudia Günther, Andreas Linkermann et al. · 2025 · eLife
- Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivationIvy M. Dambuza, Roanne S. Keeton, Nai‐Jen Hsu, Nasiema Allie, Valerie F. J. Quesniaux, Bernhard Ryffel, Muazzam Jacobs · 2016 · Scientific Reports
- The neuroprotective effects of adalimumab on rats with experimental peripheral nerve injury: an electron microscopic and biochemical study.Ergün Dağlıoğlu · 2015 · Turkish Journal of Trauma and Emergency Surgery
- Turning the immune system onJannie G. Borst, Andrew Paul Cope · 1999 · Immunology Today
- Polymorphisms of IFN-γ T/A +874 Gene and Relationship with COVID 19 in Iraqi PopulationAnwar Abed Nasser Dhabaan, Mohammad Hussein Alwan · 2021 · IOP Conference Series Earth and Environmental Science
- When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related DisordersCharles L. Raison, Andrew H. Miller · 2011 · FOCUS The Journal of Lifelong Learning in Psychiatry
- Role of Th1 Cytokines in Host Defenses Against Mycobacterium lepraeElizabeth Pereira Sampaio, Milton Ozório Moraes, María Cristina Vidal Pessolani, Euzenir Nunes Sarno · 2003 · Humana Press eBooks
- T LymphocytesRalph C. Budd, Karen A. Fortner · 2016 · Elsevier eBooks
- Cytokines and Chemokines in Virus-Induced AutoimmunityUrs Christen, Matthias G. von Herrath · 2003 · Advances in experimental medicine and biology
- Peripheral neuropathies associated with anti-tnf-α treatments: a systematic review and proposed recommendationsGiammarco Milella, Marco Sozzo, Piergiorgio Lasorella, Stefania Scannicchio, Sebastiano Carlone, Marco Fornaro, Giovanni Defazio · 2025 · Journal of Neurology
- Beneficial effect of co‐polymer 1 on cytokine production by CD4 T cells in multiple sclerosisBenoı̂t Fellay, Michel Chofflon, Catherine Juillard, Anne‐Marie Paunier, Théodor Landis, Serge Roth, Marie‐Lise Gougeon · 2001 · Immunology
- Virally induced inflammation and therapeutic avenues in type 1 diabetesUrs Christen, Amy E. Juedes, Dirk Homann, Matthias G. von Herrath · 2004 · Endocrinology and Metabolism Clinics of North America
- The Effect of Blockade of Tumor Necrosis Factor α on VLA-1+T-Cells in Rheumatoid Arthritis PatientsIlan Bank, Shomron Ben‐Horin, Itamar Goldstein, Alexander Koltakov, Pnina Langevitz, Michael Ehrenfeld, Esther Rosenthal, Hanan Guzner Gur · 2007 · Journal of Clinical Immunology
- T LymphocytesRalph C. Budd, Karen A. Fortner · 2013 · Elsevier eBooks
- Immunothérapies du lupus systémique : innovations et perspectivesJean Sibilia, Christelle Sordet · 2005 · Revue du Rhumatisme
- Biologics in the Treatment of Rheumatoid Arthritis: Mechanisms of ActionArthur Kavanaugh, Peter E. Lipsky · 2000 · KARGER eBooks
- Emotion, Interventions, and ImmunityKyung Bong Koh · 2013 · Springer eBooks
- A soluble TNF receptor 2 agonist as a new therapeutic approach to treat autoimmune and demyelinating diseasesRoman Fischer · 2011 · OPUS Publication Server of the University of Stuttgart (University of Stuttgart)
- Epstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-62000 · Pure Amsterdam UMC
- A case report: Guillain-Barré syndrome probably associated with TNF inhibitor in Blau syndromeXiqiong Han, Yingying Jin, Chenxi Liu, Hua Huang, Fei Ding, Zhen Yang, Xuemei Xu, Shengfang Bao, Liping Wang, Jing Ma et al. · 2026 · BMC Pediatrics
- Viral encephalitis related to adalimumab in a 16-year-old Crohn’s disease patient: case report and literature reviewZao Liang, Qiuping Yang, Guixian Pan, Ximei Yang, Bingqing Liu, Wenting Gan, Ruoshi Yang, Hu Hao, Sitao Li, Yao Cai · 2026 · Frontiers in Immunology
- Exploring the Pathogenesis of Rheumatoid Arthritis in Transgenic and Mutant MiceAndrew Paul Cope · 2000 · KARGER eBooks
- Cytokine Regulation of Diabetes in Experimental ModelsE. Allison Green, Richard Anthony Flavell · 2001 · KARGER eBooks
- Exploring the signalling pathways promoting T cell effector responses in chronic inflammationP. Isomäki, J. M. Clark, Panagiotis Vagenas, Andrew Paul Cope · 2002 · Modern Rheumatology
- CD4 + T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependentIulia Popescu, Mark E. Snyder, Carlo J. Iasella, Stefanie J. Hannan, Ritchie Koshy, Robin Burke, Antu Das, Mark J. Brown, Emily Lyons, Sophia C. Lieber et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- CytokinesWalter M. Lewko, Robert K. Oldham · 2003 · Springer eBooks
- Studies of pharmacological interventions and pathogenesis of rheumatoid arthritisJon Lampa · 2002 · Figshare
- Immunomodulatory effects of interferon-alpha on T cell subsets in Behcet's disease ex vivo, and the in vitro effects of treatment on healthy donor cellsDavid S. Yang · 2012 · UCL Discovery (University College London)
- Human LT-α-Mediated Resistance to Autoimmune Diabetes Is Induced in NOD, but Not NOD-Scid, Mice and Abrogated by IL-12Shuichi Miyaguchi, Jo Satoh, Kazuma Takahashi, Yoshiyuki Sakata, Tetsuya NAKAZAWA, Jun‐ichi Miyazaki, Takayoshi Toyota · 2001 · Clinical Immunology
- Effect of anti-TNF therapy on T cell activation and effector functions in patients with chronic inflammatory diseasesLorenzo Raeli · 2009 · BOA (University of Milano-Bicocca)
- Physiological Role of TNF in Mucosal Immunology: Regulation of T-Cell FunctionMichael M. Scharl · 2015 · Frontiers of gastrointestinal research
- Characterization of an autoimmune gene expression signature.Kevin H. Maas · 2006
- Tumor Necrosis Factor _ and Interleukin-1_ Inhibitory TherapiesJOHAN C. KIPS, ROMAIN A. PAUWELS · 2002 · Lung biology in health and disease
- Biological Agents for Chronic Inflammatory Demyelinating PolyradiculoneuropathyJoerg‐Patrick Stübgen · 2012 · European Neurological Review
- Immunological Methods and the Concept of Inflammaging in the Study of Human AgingTamàs Fülöp, Graham Pawelec, Jacek Maciej Witkowski, Alan Arthur Cohen, Carl F Fortin, Aurélie Y. Le Page, Hugo Garneau, Gilles Dupuis, Anis Larbi · 2018 · Elsevier eBooks
- Differential effects of anti-TNF therapies for inflammatory arthritides on immune responses to Mycobacterium tuberculosisRachel Byng-Maddick · 2018 · UCL Discovery (University College London)
- T LymphocytesRalph C. Budd, Karen A. Fortner · 2009 · Elsevier eBooks
- Data from Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck CancerLisheng Ge, Dejan Baskić, Per H. Basse, Lazar N. Vujanovic, Sebnem Unlu, Toshie Yoneyama, Andrea Vujanovic, Jie Han, Dragić Banković, Mirosław J. Szczepański et al. · 2023
- Data from Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck CancerLisheng Ge, Dejan Baskić, Per H. Basse, Lazar N. Vujanovic, Sebnem Unlu, Toshie Yoneyama, Andrea Vujanovic, Jie Han, Dragić Banković, Mirosław J. Szczepański et al. · 2023
- Comportamento imunocelular e suscetibilidade a infecções no diabetes mellitus tipo 1C Barbosa · 2002 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Prostaglandin D2 delays CD8+ T-cell responses and respiratory syncytial virus clearance in geriatric cotton ratsJonathan L. Miller, Cameron Leedale, Danyue Kang, Jingtao Lilue, Olivia E. Harder, Stefan Niewiesk · 2025 · Journal of Virology
- Characterisation of cytokine expression in early synovitis and established rheumatoid arthritisLorraine Yeo · 2012 · University of Birmingham Institutional Research Archive (University of Birmingham)
- Etude du rôle de NF-kB dans les lymphocytes T régulateurs chez la sourisÉmilie Ronin · 2017 · theses.fr (ABES)
- Reduced inflammatory and Th1 transcriptional profiles in geriatric versus adult cotton rats infected with respiratory syncytial virusJonathan Miller, Cameron Leedale, Ayse Selen Yilmaz, Emily Pawlack, Jessica Gomez Garrido, Tyler Alioto, Lianbo Yu, David E. Symer, Stefan Niewiesk · 2026 · PLoS Pathogens
- Fenotipagem das populações celulares e detecção in situ de citocinas em biópsias de pacientes com paracoccidioidomicoseTânia M. Alcântara · 2002 · Americanae (AECID Library)
- A UTOIMMUNE D ISEASESR. M Ackay, S. R Osen, A Nne, B Etty D Iamond · 2001
- Untitled work1999 · 10.1002/(sici)1521-4141(199903)29:03