Cited by 287T-cell and B-cell ImmunologyRheumatoid Arthritis Research and TherapiesCytokine Signaling Pathways and Interactions

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Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

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Cope, Andrew P., Liblau, Roland S., Yang, Xiao-Dong, Congia, Mauro, Laudanna, Carlo, Schreiber, Robert D., Probert, Lesley, Kollias, George, McDevitt, Hugh O.·1997·The Journal of Experimental Medicine

DOI 10.1084/jem.185.9.1573PMC PMC2196294

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Abstract

Repeated injections of adult mice with recombinant murine TNF prolong the survival of NZB/W F1 mice, and suppress type I insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. To determine whether repeated TNF injections suppress T cell function in adult mice, we studied the responses of influenza hemagglutinin-specific T cells derived from T cell receptor (HNT-TCR) transgenic mice. Treatment of adult mice with murine TNF for 3 wk suppressed a broad range of T cell responses, including proliferation and cytokine production. Furthermore, T cell responses of HNT-TCR transgenic mice also expressing the human TNF-globin transgene were markedly reduced compared to HNT-TCR single transgenic littermates, indicating that sustained p55 TNF-R signaling is sufficient to suppress T cell function in vivo. Using a model of chronic TNF exposure in vitro, we demonstrate that (a) chronic TNF effects are dose and time dependent, (b) TNF suppresses the responses of both Th1 and Th2 T helper subsets, (c) the suppressive effects of endogenous TNF produced in T cell cultures could be reversed with neutralizing monoclonal antibodies to TNF, and (d) prolonged TNF exposure attenuates T cell receptor signaling. The finding that anti-TNF treatment in vivo enhances T cell proliferative responses and cytokine production provides evidence for a novel regulatory effect of TNF on T cells in healthy laboratory mice. These effects are more pronounced in chronic inflammatory disease. In addition, our data provide a mechanism through which prolonged TNF exposure suppresses disease in animal models of autoimmunity.

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Authors: Cope, A. P., Liblau, R. S., Yang, X.-D., Congia, M., Laudanna, C., Schreiber, R. D., Probert, L., Kollias, G., & McDevitt, H. O.
Affiliations: Washington University in St. Louis (US)
From the *Department of Microbiology and Immunology, ‡Department of Pathology, and §Department of Medicine, Stanford University School of Medicine, Stanford, California 94305; ‖Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110; and ¶Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
ORCID: Cope, Andrew P.
Liblau, Roland S.
Congia, Mauro
Laudanna, Carlo
Schreiber, Robert D.
Probert, Lesley
Kollias, George
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1997-05-05
Volume: 185
Issue: 9
Pages: 1573-1584
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.185.9.1573
PMC: PMC2196294
OpenAlex: W2153191296
Cited by: 287
References: 38
Citations by year: 2026: 3 · 2025: 4 · 2023: 4 · 2022: 1 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 6 · 2014: 11 · 2013: 8 · 2012: 13
FWCI: 8.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: Wellcome Trust
Institut National de la Santé et de la Recherche Médicale
National Institutes of Health
School of Medicine, Stanford University
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: TNF-α, T cell receptor signaling, T cell suppression, TNF receptor p55, T cell proliferation, cytokine production, anti-TNF therapy, autoimmunity, type 1 diabetes, chronic inflammation
MeSH terms: Animals, Calcium, Immunosuppressive Agents, Interferon-gamma, Interleukin-2, Lymph Nodes, Lymphocyte Activation, Male, Mice, Inbred BALB C, Mice, Transgenic, Receptors, Antigen, T-Cell, Recombinant Proteins, T-Lymphocytes, Tumor Necrosis Factor-alpha, Signal Transduction, CD4-Positive T-Lymphocytes, Interleukin-4, Interleukin-10, Receptors, Tumor Necrosis Factor, Th1 Cells, Th2 Cells, Mice

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Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

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