The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors
Open accessAbstract
Lipoxins are bioactive eicosanoids that are immunomodulators. In human myeloid cells, lipoxin (LX) A4 actions are mediated by interaction with a G protein–coupled receptor. To explore functions of LXA4 and aspirin-triggered 5(S),6(R),15(R)-trihydroxy-7,9,13-trans-11-cis–eicosatetraenoic acid (15-epi-LXA4) in vivo, we cloned and characterized a mouse LXA4 receptor (LXA4R). When expressed in Chinese hamster ovary cells, the mouse LXA4R showed specific binding to [3H]LXA4 (Kd ≈ 1.5 nM), and with LXA4 activated GTP hydrolysis. Mouse LXA4R mRNA was most abundant in neutrophils. In addition to LXA4 and 15-epi-LXA4, bioactive LX stable analogues competed with both [3H]LXA4 and [3H]leukotriene D4 (LTD4)– specific binding in vitro to neutrophils and endothelial cells, respectively. Topical application of LXA4 analogues and novel aspirin-triggered 15-epi-LXA4 stable analogues to mouse ears markedly inhibited neutrophil infiltration in vivo as assessed by both light microscopy and reduced myeloperoxidase activity in skin biopsies. The 15(R)-16-phenoxy-17,18, 19,20-tetranorLXA4 methyl ester (15-epi-16-phenoxy-LXA4), an analogue of aspirin triggered 15-epi-LXA4, and 15(S)-16-phenoxy-17,18,19,20-tetranor-LXA4 methyl ester (16-phenoxy-LXA4) were each as potent as equimolar applications of the anti-inflammatory, dexamethasone. Thus, we identified murine LXA4R, which is highly expressed on murine neutrophils, and showed that both LXA4 and 15-epi-LXA4 stable analogues inhibit neutrophil infiltration in the mouse ear model of inflammation. These findings provide direct in vivo evidence for an anti-inflammatory action for both aspirin-triggered LXA4 and LXA4 stable analogues and their site of action in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,116
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5263.872 · Cited by 4,172
Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
Bradley, P. P., Priebat, D. A., Christensen, R. D., & Rothstein, G. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12506462 · Cited by 3,626
STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS
Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D., & Dixon, R. A. F. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000533 · Cited by 1,079
Clària, J., & Serhan, C. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9475 · Cited by 700
Self-citationGenis, P., Jett, M., Bernton, E. W., Boyle, T., Gelbard, H. A., Dzenko, K., Keane, R. W., Resnick, L., Mizrachi, Y., & Volsky, D. J. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.6.1703 · Cited by 531
ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULES IN HUMAN DISEASE
Bevilacqua, M. D., Nelson, P. D., Mannori, M. D., & Cecconi, M. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.361 · Cited by 456
Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.
Fiore, S., Maddox, J. F., Perez, H. D., & Serhan, C. N. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.1.253 · Cited by 436
Self-citationLipid mediator networks in cell signaling: update and impact of cytokines 1
Serhan, C. N., Haeggström, J. Z., & Leslie, C. C. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.10.8751717 · Cited by 394
Self-citationDesign of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils
Serhan, C. N., Maddox, J. F., Petasis, N. A., Akritopoulou-Zanze, I., Papayianni, A., Brady, H. R., Colgan, S. P., & Madara, J. L. (1995) · Biochemistry · doi:10.1021/bi00044a041 · Cited by 327
Self-citation
Cited by
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Self-citationResolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996
Self-citationInflammatory Mediators of Asthma: An Update
Barnes, P. J., Chung, K. F., & Page, C. P. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01381-4 · Cited by 717
Godson, C., Mitchell, S., Harvey, K., Petasis, N. A., Hogg, N., & Brady, H. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1663 · Cited by 638
Self-citationThematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
Buczynski, M. W., Dumlao, D. S., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900004-jlr200 · Cited by 530
Metadata
- Authors
- Takano, T., Fiore, S., Maddox, J. F., Brady, H. R., Petasis, N. A., & Serhan, C. N.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1997-05-05
- Volume
- 185
- Issue
- 9
- Pages
- 1693-1704
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2162382352
- Cited by
- 431
- References
- 26
- FWCI
- 20.87
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors. https://app.cochat.ai/papers/10.1084/jem.185.9.1693
- The paper
- Takano, T., Fiore, S., Maddox, J. F., Brady, H. R., Petasis, N. A., & Serhan, C. N. (1997). Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.185.9.1693
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
