Resolvins and protectins in inflammation resolution

Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice

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Exploring the full spectrum of macrophage activation

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Cytokine-mediated regulation of CXCR4 expression in human neutrophils

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The Pathophysiology and Treatment of Sepsis

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Nitric oxide: an endogenous modulator of leukocyte adhesion.

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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

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Resolution of inflammation: the beginning programs the end

Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works

n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases

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Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

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Immunodesign of experimental sepsis by cecal ligation and puncture

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The immune response in atherosclerosis: a double-edged sword

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Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

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Eicosanoids and cancer

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Resolvins

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Lipid mediator class switching during acute inflammation: signals in resolution

Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works

Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003*

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Inducible cyclooxygenase may have anti-inflammatory properties

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Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

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Resolvin E1 and protectin D1 activate inflammation-resolution programmes

Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works

Macrophage death and defective inflammation resolution in atherosclerosis

Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

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Resolution of in flammation: state of the art, definitions and terms

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Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works

Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving Lipid Mediators and Pathways

Serhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works

Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms

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Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

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Mechanisms of action of docosahexaenoic acid in the nervous system

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Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions

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A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

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The discovery of nitric oxide and its role in vascular biology

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Anti-inflammatory lipid mediators and insights into the resolution of inflammation

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Environment and Disease Risks

Rappaport, S. M., & Smith, M. T. (2010) · Science · doi:10.1126/science.1192603 · Cited by 850 · see citing works

Animal Models of sepsis: setting the stage

Buras, J. A., Holzmann, B., & Sitkovsky, M. V. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1854 · Cited by 838 · see citing works

Interactions between the immune and nervous systems in pain

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Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression

Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works

Inflammatory Resolution: new opportunities for drug discovery

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Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · see citing works

Platelet-Activating Factor and Related Lipid Mediators

Prescott, S. M., Zimmerman, G. A., Stafforini, D. M., & McIntyre, T. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.419 · Cited by 747 · see citing works

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C., Yang, R., Petasis, N. A., & Serhan, C. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907342107 · Cited by 738 · see citing works

Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins

Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S., & Serhan, C. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4345 · Cited by 699 · see citing works

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., & Serhan, C. N. (2009) · Nature · doi:10.1038/nature08541 · Cited by 695 · see citing works

Increased dietary intake of ω-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis

Connor, K. M., SanGiovanni, J. P., Löfqvist, C., Aderman, C. M., Chen, J., Higuchi, A., Hong, S., Pravda, E. A., Majchrzak, S. F., Carper, D. A., et al. (2007) · Nature Medicine · doi:10.1038/nm1591 · Cited by 687 · see citing works

Robbins Pathologic Basis of Disease

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Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

Godson, C., Mitchell, S., Harvey, K., Petasis, N. A., Hogg, N., & Brady, H. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1663 · Cited by 638 · see citing works

Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation

Arita, M., Ohira, T., Sun, Y., Elangovan, S., Chiang, N., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3912 · Cited by 636 · see citing works

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

Xu, Z., Zhang, L., Liu, T., Park, J. Y., Berta, T., Yang, R., Serhan, C. N., & Ji, R. (2010) · Nature Medicine · doi:10.1038/nm.2123 · Cited by 593 · see citing works

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., Blumberg, R. S., & Serhan, C. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409271102 · Cited by 590 · see citing works

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

Shimizu, T. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145616 · Cited by 577 · see citing works

Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins

González‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 556 · see citing works

Resolvin D1 and Its Aspirin-triggered 17R Epimer

Sun, Y., Oh, S. F., Uddin, J., Yang, R., Gotlinger, K. H., Campbell, E. L., Colgan, S. P., Petasis, N. A., & Serhan, C. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609212200 · Cited by 541 · see citing works

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

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COX-2 and beyond: approaches to prostaglandin inhibition in human disease

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PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

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Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality

Osuchowski, M. F., Welch, K. B., Siddiqui, J., & Remick, D. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1967 · Cited by 511 · see citing works

Metabolic oxidation regulates embryonic stem cell differentiation

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5-Lipoxygenase: regulation of expression and enzyme activity

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Specialized pro-resolving lipid mediators in the inflammatory response: An update

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Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

Serhan, C. N. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.05.002 · Cited by 459 · see citing works

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

Serhan, C. N., Gotlinger, K. H., Hong, S., Lu, Y., Siegelman, J. N., Baer, T. E., Yang, R., Colgan, S. P., & Petasis, N. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1848 · Cited by 457 · see citing works

RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis

Hastürk, H., Kantarcı, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Dyke, T. E. V. (2005) · The FASEB Journal · doi:10.1096/fj.05-4724fje · Cited by 437 · see citing works

Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors

Takano, T., Fiore, S., Maddox, J. F., Brady, H. R., Petasis, N. A., & Serhan, C. N. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1693 · Cited by 433 · see citing works

Endogenous pro‐resolving and anti‐inflammatory lipid mediators: a new pharmacologic genus

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Resolvin E1 regulates interleukin 23, interferon-γ and lipoxin A4 to promote the resolution of allergic airway inflammation

Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., & Levy, B. D. (2008) · Nature Immunology · doi:10.1038/ni.1627 · Cited by 425 · see citing works

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421 · see citing works

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

Serhan, C. N., Jain, A., Marleau, S., Clish, C. B., Kantarcı, A., Behbehani, B., Colgan, S. P., Stahl, G. L., Merched, A. J., Petasis, N. A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6856 · Cited by 405 · see citing works

n−3 Fatty acids and cardiovascular disease

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Immunomodulation by omega-3 fatty acids

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Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness

Levy, B. D., Kohli, P., Gotlinger, K. H., Haworth, O., Hong, S., Kazani, S. D., Israel, E., Haley, K. J., & Serhan, C. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.496 · Cited by 357 · see citing works

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

Levy, B. D., Sanctis, G. T. D., Devchand, P. R., Kim, E., Ackerman, K. G., Schmidt, B. A. R., Szczeklik, W., Drazen, J. M., & Serhan, C. N. (2002) · Nature Medicine · doi:10.1038/nm748 · Cited by 350 · see citing works

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

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n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: A review

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Prostaglandin catabolizing enzymes

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Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury

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Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

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Atherosclerosis: The New View

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Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese‐diabetic mice

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Cells, tissues, and disease : principles of general pathology

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Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

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Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

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Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.

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Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic Neutrophils In Vivo

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Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

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The Macrophage Scavenger Receptor Type A Is Expressed by Activated Macrophages and Protects the Host Against Lethal Endotoxic Shock

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Lipoxin biosynthesis and its impact in inflammatory and vascular events

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Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor

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Therapeutic options for 5-lipoxygenase inhibitors

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Lipoxin A 4 and aspirin-triggered 15-epi-lipoxin A 4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes

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Hematopoietic prostaglandin D 2 synthase controls the onset and resolution of acute inflammation through PGD 2 and 15-deoxyΔ 12–14 PGJ 2

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The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

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Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): A jungle of cell-cell interactions or a therapeutic opportunity?

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Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

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