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Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
Open accessAbstract
Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor–deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.
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Citations
Cited by
Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis
Vadas, P., Gold, M., Perelman, B., Liss, G. M., Lack, G., Blyth, T., Simons, F. E. R., Simons, K. J., Cass, D., & Yeung, J. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070030 · Cited by 526
The pathophysiology of anaphylaxis
Reber, L. L., Hernandez, J. D., & Galli, S. J. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.06.003 · Cited by 507
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Ishii, S., & Shimizu, T. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00016-8 · Cited by 384
Self-citationMutant G-protein-coupled receptors as a cause of human diseases
Schöneberg, T., Schulz, A., Biebermann, H., Hermsdorf, T., Römpler, H., & Sangkuhl, K. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.008 · Cited by 337
Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2
Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., & Shimizu, T. (2000) · Nature Immunology · doi:10.1038/76897 · Cited by 302
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Metadata
- Authors
- Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W.-H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J.-I., Kumada, M., & Shimizu, T.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-06-01
- Volume
- 187
- Issue
- 11
- Pages
- 1779-1788
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2151923841
- Cited by
- 281
- References
- 0
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor. https://app.cochat.ai/papers/10.1084/jem.187.11.1779
- The paper
- Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W.-H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J.-I., Kumada, M., & Shimizu, T. (1998). Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.187.11.1779
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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