The DOI matches its Crossref record; 195 of the 195 references it cites were found in a registry or an index.
The pathophysiology of anaphylaxis
Open accessAbstract
Anaphylaxis is a severe, systemic hypersensitivity reaction that is rapid in onset and characterized by life-threatening airway, breathing, and/or circulatory problems, and that is usually associated with skin and mucosal changes. Because it can be triggered in some people by minute amounts of antigen (e.g. certain foods or single insect stings), anaphylaxis can be considered the most aberrant example of an imbalance between the cost and benefit of an immune response. This review will describe current understanding of the immunopathogenesis and pathophysiology of anaphylaxis, focusing on the roles of IgE and IgG antibodies, immune effector cells, and mediators thought to contribute to examples of the disorder. Evidence from studies of anaphylaxis in humans will be discussed, as well as insights gained from analyses of animal models, including mice genetically deficient in the antibodies, antibody receptors, effector cells, or mediators implicated in anaphylaxis, and mice which have been “humanized” for some of these elements. We also will review possible host factors which may influence the occurrence or severity of anaphylaxis. Finally, we will speculate about anaphylaxis from an evolutionary perspective, and argue that, in the context of severe envenomation by arthropods or reptiles, anaphylaxis may even provide a survival advantage.
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Self-citationAllergic reactions and anaphylaxis to LNP-based COVID-19 vaccines
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Starkl, P., Watzenboeck, M. L., Popov, L. M., Zahalka, S., Hladik, A., Lakovits, K., Radhouani, M., Haschemi, A., Marichal, T., Reber, L. L., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.002 · Cited by 59
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Metadata
- Authors
- Reber, L. L., Hernandez, J. D., & Galli, S. J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 140
- Issue
- 2
- Pages
- 335-348
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2744715029
- Cited by
- 507
- References
- 195
- FWCI
- 22.44
- Type
- journal article
- Language
- en
- Open access
- green
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