The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen
Open accessAbstract
We investigated CD4+ and CD8+ T cell turnover in both healthy and HIV-1–infected adults by measuring the nuclear antigen Ki-67 specific for cell proliferation. The mean growth fraction, corresponding to the expression of Ki-67, was 1.1% for CD4+ T cells and 1.0% in CD8+ T cells in healthy adults, and 6.5 and 4.3% in HIV-1–infected individuals, respectively. Analysis of CD45RA+ and CD45RO+ T cell subsets revealed a selective expansion of the CD8+ CD45RO+ subset in HIV-1–positive individuals. On the basis of the growth fraction, we derived the potential doubling time and the daily turnover of CD4+ and CD8+ T cells. In HIV-1–infected individuals, the mean potential doubling time of T cells was five times shorter than that of healthy adults. The mean daily turnover of CD4+ and CD8+ T cells in HIV-1–infected individuals was increased 2- and 6-fold, respectively, with more than 40-fold interindividual variation. In patients with <200 CD4+ counts, CD4+ turnover dropped markedly, whereas CD8+ turnover remained elevated. The large variations in CD4+ T cell turnover might be relevant to individual differences in disease progression.
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Cites
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Cited by
Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
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T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock
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HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation
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Homeostatic control of T-cell generation in neonates
Schönland, S. O., Zimmer, J. K., Lopez-Benitez, C. M., Widmann, T., Ramin, K. D., Goronzy, J. J., & Weyand, C. M. (2003) · Blood · doi:10.1182/blood-2002-11-3591 · Cited by 178
Metadata
- Authors
- Sachsenberg, N., Perelson, A. S., Yerly, S., Schockmel, G. A., Leduc, D., Hirschel, B., & Perrin, L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-04-20
- Volume
- 187
- Issue
- 8
- Pages
- 1295-1303
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2114497207
- Cited by
- 329
- References
- 30
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen. https://app.cochat.ai/papers/10.1084/jem.187.8.1295
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- Sachsenberg, N., Perelson, A. S., Yerly, S., Schockmel, G. A., Leduc, D., Hirschel, B., & Perrin, L. (1998). Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.187.8.1295
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
