The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation
Open accessAbstract
The supply of naive T cells by the thymus normally requires precursor T cell proliferation within the thymus and would be particularly important in the setting of HIV infection when both naive and memory T cells are progressively depleted. As a robust, quantitative index of intrathymic proliferation, the ratio of different T cell receptor excision circles (TRECs), molecular markers of distinct T cell receptor rearrangements occurring at different stages of thymocyte development, was measured in peripheral blood-mononuclear cells (PBMCs). This ratio has the virtue that it is a "signature" of thymic emigrants throughout their entire life and, thus, can be measured in peripheral cell populations that are easy to obtain. Using the new assay, we evaluated the effect of HIV infection on intrathymic precursor T cell proliferation by longitudinal analysis of PBMCs from recently infected individuals. Our findings reveal a substantial reduction in intrathymic proliferation. The analysis also indicates the existence of a compensatory mechanism acting to sustain the numbers of recent thymic emigrants (RTEs) in the periphery.
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Cites
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
A Direct Estimate of the Human αβ T Cell Receptor Diversity
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P. (1999) · Science · doi:10.1126/science.286.5441.958 · Cited by 931
CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?
Grossman, Z., Meier-Schellersheim, M., Sousa, A. E., Victorino, R. M. M., & Paul, W. E. (2002) · Nature Medicine · doi:10.1038/nm0402-319 · Cited by 450
Self-citationHazenberg, M. D., Stuart, J. W. T. C., Otto, S. A., Borleffs, J. C. C., Boucher, C. A. B., de Boer, R. J., Miedema, F., & Hamann, D. (2000) · Blood · doi:10.1182/blood.v95.1.249 · Cited by 450
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Hazenberg, M. D., Otto, S. A., Stuart, J. W. T. C., Verschuren, M. C. M., Borleffs, J. C. C., Boucher, C. A. B., Coutinho, R. A., Lange, J. M. A., de Wit, T. F. R., Tsegaye, A., et al. (2000) · Nature Medicine · doi:10.1038/79549 · Cited by 394
T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock
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Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen
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Cited by
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans
den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572
HIV disease: fallout from a mucosal catastrophe?
Brenchley, J. M., Price, D. A., & Douek, D. C. (2006) · Nature Immunology · doi:10.1038/ni1316 · Cited by 579
CD8+ T cell efficacy in vaccination and disease
Appay, V., Douek, D. C., & Price, D. A. (2008) · Nature Medicine · doi:10.1038/nm.f.1774 · Cited by 393
The molecular basis for public T-cell responses?
Venturi, V., Price, D. A., Douek, D. C., & Davenport, M. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2260 · Cited by 342
T cell immune reconstitution following lymphodepletion
Williams, K. M., Hakim, F. T., & Gress, R. E. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.004 · Cited by 340
Metadata
- Authors
- Dion, M.-L., Poulin, J.-F., Bordi, R., Sylvestre, M., Corsini, R., Kettaf, N., Dalloul, A., Boulassel, M.-R., Debré, P., Routy, J.-P., Grossman, Z., Sékaly, R.-P., & Cheynier, R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 21
- Issue
- 6
- Pages
- 757-768
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2005176636
- Cited by
- 260
- References
- 39
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation. https://app.cochat.ai/papers/10.1016/j.immuni.2004.10.013
- The paper
- Dion, M.-L., Poulin, J.-F., Bordi, R., Sylvestre, M., Corsini, R., Kettaf, N., Dalloul, A., Boulassel, M.-R., Debré, P., Routy, J.-P., Grossman, Z., Sékaly, R.-P., & Cheynier, R. (2004). HIV Infection Rapidly Induces and Maintains a Substantial Suppression of Thymocyte Proliferation. Immunity. https://doi.org/10.1016/j.immuni.2004.10.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
