The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
A Critical Role of Natural Immunoglobulin M in Immediate Defense Against Systemic Bacterial Infection
Open accessAbstract
To evaluate the role of natural immunoglobulin (Ig)M in the immediate response against microbial infection, we tested mutant mice that are deficient in secreted (s)IgM in an acute peritonitis model induced by cecal ligation and puncture (CLP). 20% of wild-type mice died within 32 h of CLP, whereas 70% of sIgM-deficient mice died within the same time period. The increased susceptibility was associated with a reduced level of tumor necrosis factor (TNF)-α, a decreased neutrophil recruitment and an increased bacterial load in the peritoneum, and elevated levels of endotoxin and proinflammatory cytokines in the circulation. Resistance to CLP by sIgM-deficient mice was restored by reconstitution with polyclonal IgM from normal mouse serum. Reconstitution with a monoclonal IgM specific to phosphatidylcholine, a conserved cell membrane component, has a modest effect but a monoclonal IgM specific to phosphocholine is not protective. These findings demonstrate a critical role of natural IgM in the immediate defense against severe bacterial infection.
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Joffre, O. P., Segura, E., Savina, A., & Amigorena, S. (2012) · Nature Reviews Immunology · doi:10.1038/nri3254 · Cited by 1,637
The complement system in regulation of adaptive immunity
Carroll, M. C. (2004) · Nature Immunology · doi:10.1038/ni1113 · Cited by 1,035
Self-citationThe double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
Origins and Functions of B-1 Cells with Notes on the Role of CD5
Berland, R., & Wortis, H. H. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064833 · Cited by 745
Griffin, D. O., Holodick, N. E., & Rothstein, T. L. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101499 · Cited by 615
Metadata
- Authors
- Boes, M., Prodeus, A. P., Schmidt, T., Carroll, M. C., & Chen, J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-12-21
- Volume
- 188
- Issue
- 12
- Pages
- 2381-2386
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2159490575
- Cited by
- 554
- References
- 32
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Boes, M., Prodeus, A. P., Schmidt, T., Carroll, M. C., & Chen, J. (1998). A Critical Role of Natural Immunoglobulin M in Immediate Defense Against Systemic Bacterial Infection. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.12.2381
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
