The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein
Open accessAbstract
Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 (DRB1*1501) haplotype. The structure of HLA-DR2 was determined with a bound peptide from human myelin basic protein (MBP) that is immunodominant for human MBP-specific T cells. Residues of MBP peptide that are important for T cell receptor recognition are prominent, solvent exposed residues in the crystal structure. A distinguishing feature of the HLA-DR2 peptide binding site is a large, primarily hydrophobic P4 pocket that accommodates a phenylalanine of the MBP peptide. The necessary space for this aromatic side chain is created by an alanine at the polymorphic DRβ 71 position. These features make the P4 pocket of HLA-DR2 distinct from DR molecules associated with other autoimmune diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Jones, T. A., Zou, J. Y., Cowan, S. W., & Kjeldgaard, M. (1991) · Acta Crystallographica Section A Foundations of Crystallography · doi:10.1107/s0108767390010224 · Cited by 12,648
Nicholls, A., Sharp, K. A., & Honig, B. (1991) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340110407 · Cited by 5,240
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures
Brünger, A. T. (1992) · Nature · doi:10.1038/355472a0 · Cited by 3,873
Gregersen, P. K., Silver, J., & Winchester, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,599
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1993) · Nature · doi:10.1038/364033a0 · Cited by 2,379
Self-citationJohnson, K. P., Brooks, B. R., Cohen, J. A., Ford, C. C., Goldstein, J., Lisak, R. P., Myers, L. W., Panitch, H. S., Rose, J. W., Schiffer, R. B., et al. (1995) · Neurology · doi:10.1212/wnl.45.7.1268 · Cited by 1,898
Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1994) · Nature · doi:10.1038/368215a0 · Cited by 1,555
Self-citationWucherpfennig, K. W., & Strominger, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90348-8 · Cited by 1,534
Self-citationStructure of the complex between human T-cell receptor, viral peptide and HLA-A2
Garboczi, D. N., Ghosh, P., Utz, U., Fan, Q. R., Biddison, W. E., & Wiley, D. C. (1996) · Nature · doi:10.1038/384134a0 · Cited by 1,424
Self-citation
Cited by
Mechanisms for the induction of autoimmunity by infectious agents
Wucherpfennig, K. W. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14235 · Cited by 435
Self-citationMHC class II proteins and disease: a structural perspective
Jones, E. Y., Fugger, L., Strominger, J. L., & Siebold, C. (2006) · Nature Reviews Immunology · doi:10.1038/nri1805 · Cited by 411
The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
Oksenberg, J. R., Baranzini, S. E., Sawcer, S., & Hauser, S. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2395 · Cited by 347
Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans
Oksenberg, J. R., Barcellos, L. F., Cree, B. A. C., Baranzini, S. E., Bugawan, T. L., Khan, O., Lincoln, R. R., Swerdlin, A., Mignot, E., Lin, L., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/380997 · Cited by 340
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
Barcellos, L. F., Sawcer, S., Ramsay, P. P., Baranzini, S. E., Thomson, G., Briggs, F., Cree, B. C. A., Begovich, A. B., Villoslada, P., Montalban, X., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl223 · Cited by 317
Metadata
- Authors
- Smith, K. J., Pyrdol, J., Gauthier, L., Wiley, D. C., & Wucherpfennig, K. W.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1998-10-19
- Volume
- 188
- Issue
- 8
- Pages
- 1511-1520
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2102938736
- Cited by
- 294
- References
- 51
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein. https://app.cochat.ai/papers/10.1084/jem.188.8.1511
- The paper
- Smith, K. J., Pyrdol, J., Gauthier, L., Wiley, D. C., & Wucherpfennig, K. W. (1998). Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.188.8.1511
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
