The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Contribution of Nitric Oxide Synthases 1, 2, and 3 to Airway Hyperresponsiveness and Inflammation in a Murine Model of Asthma
Open accessAbstract
Asthma is a chronic disease characterized by increased airway responsiveness and airway inflammation. The functional role of nitric oxide (NO) and the various nitric oxide synthase (NOS) isoforms in human asthma is controversial. To investigate the role of NO in an established model of allergic asthma, mice with targeted deletions of the three known isoforms of NOS (NOS1, 2, and 3) were studied. Although the inducible (NOS2) isoform was significantly upregulated in the lungs of ovalbumin (OVA)-sensitized and -challenged (OVA/OVA) wild-type (WT) mice and was undetectable in similarly treated NOS2-deficient mice, airway responsiveness was not significantly different between these groups. OVA/OVA endothelial (NOS3)-deficient mice were significantly more responsive to methacholine challenge compared with similarly treated NOS1 and NOS1&3-deficient mice. Airway responsiveness in OVA/OVA neuronal (NOS1)-deficient and neuronal/endothelial (NOS1&3) double-deficient mice was significantly less than that observed in similarly treated NOS2 and WT groups. These findings demonstrate an important function for the nNOS isoform in controlling the inducibility of airway hyperresponsiveness in this model of allergic asthma.
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Citations
Cites
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070
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Cited by
Dweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539
Nitric oxide in immunity and inflammation
Coleman, J. W. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00086-8 · Cited by 945
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Inducible Nitric Oxide Synthase and Inflammatory Diseases
Zamora, R., Vodovotz, Y., & Billiar, T. R. (2000) · Molecular Medicine · doi:10.1007/bf03401781 · Cited by 558
Exhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507
Metadata
- Authors
- De Sanctis, G. T., MacLean, J. A., Hamada, K., Mehta, S., Scott, J. A., Jiao, A., Yandava, C. N., Kobzik, L., Wolyniec, W. W., Fabian, A. J., Venugopal, C. S., Grasemann, H., Huang, P. L., & Drazen, J. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-05-17
- Volume
- 189
- Issue
- 10
- Pages
- 1621-1630
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2160886248
- Cited by
- 215
- References
- 1
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Contribution of Nitric Oxide Synthases 1, 2, and 3 to Airway Hyperresponsiveness and Inflammation in a Murine Model of Asthma. https://app.cochat.ai/papers/10.1084/jem.189.10.1621
- The paper
- De Sanctis, G. T., MacLean, J. A., Hamada, K., Mehta, S., Scott, J. A., Jiao, A., Yandava, C. N., Kobzik, L., Wolyniec, W. W., Fabian, A. J., Venugopal, C. S., Grasemann, H., Huang, P. L., & Drazen, J. M. (1999). Contribution of Nitric Oxide Synthases 1, 2, and 3 to Airway Hyperresponsiveness and Inflammation in a Murine Model of Asthma. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.10.1621
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
