The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity
Open accessAbstract
Contact hypersensitivity (CHS) is a T cell–mediated skin inflammation induced by epicutaneous exposure to haptens in sensitized individuals. We have previously reported that CHS to dinitrofluorobenzene in mice is mediated by major histocompatibility complex (MHC) class I–restricted CD8+ T cells. In this study, we show that CD8+ T cells mediate the skin inflammation through their cytotoxic activity. The contribution of specific cytotoxic T lymphocytes (CTLs) to the CHS reaction was examined both in vivo and in vitro, using mice deficient in perforin and/or Fas/Fas ligand (FasL) pathways involved in cytotoxicity. Mice double deficient in perforin and FasL were able to develop hapten-specific CD8+ T cells in the lymphoid organs but did not show CHS reaction. However, they did not generate hapten-specific CTLs, demonstrating that the CHS reaction is dependent on cytotoxic activity. In contrast, Fas-deficient lpr mice, FasL-deficient gld mice, and perforin-deficient mice developed a normal CHS reaction and were able to generate hapten-specific CTLs, suggesting that CHS requires either the Fas/FasL or the perforin pathway. This was confirmed by in vitro studies showing that the hapten-specific CTL activity was exclusively mediated by MHC class I–restricted CD8+ T cells which could use either the perforin or the Fas/FasL pathway for their lytic activity. Thus, cytotoxic CD8+ T cells, commonly implicated in the host defence against tumors and viral infections, could also mediate harmful delayed-type hypersensitivity reactions.
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Cites
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Self-citationFas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity
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Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
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Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
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Mice lacking MHC class II molecules
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Cited by
Effector and regulatory mechanisms in allergic contact dermatitis
Vocanson, M., Hennino, A., Rozières, A., Poyet, G., & Nicolas, J. ‐. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02082.x · Cited by 361
Self-citationCD8+ Cytotoxic T Cells Induce Relapsing Colitis in Normal Mice
Nancey, S., Holvöet, S., Graber, I., Joubert, G., Philippe, D., Martin, S., Nicolas, J., Desreumaux, P., Flourié, B., & Kaiserlian, D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.018 · Cited by 112
Self-citationFortino, V., Wisgrill, L., Werner, P., Suomela, S., Linder, N., Jalonen, E., Suomalainen, A., Marwah, V., Kero, M., Pesonen, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009192117 · Cited by 99
Metadata
- Authors
- Kehren, J., Desvignes, C., Krasteva, M., Ducluzeau, M.-T., Assossou, O., Horand, F., Hahne, M., Kägi, D., Kaiserlian, D., & Nicolas, J.-F.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-03-01
- Volume
- 189
- Issue
- 5
- Pages
- 779-786
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2073761101
- Cited by
- 262
- References
- 34
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kehren, J., Desvignes, C., Krasteva, M., Ducluzeau, M.-T., Assossou, O., Horand, F., Hahne, M., Kägi, D., Kaiserlian, D., & Nicolas, J.-F. (1999). Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.5.779
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