The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
Abstract
Major histocompatibility class I proteins display viral and self antigens to potentially responsive cells and are important for the maturation of T cells; β 2 -microglobulin (β 2 M) is required for their normal expression. Mouse chimeras derived from embryonic stem cells with a disrupted β 2 M gene transmitted the inactivated gene to their progeny. Animals homozygous for the mutated β 2 M gene were obtained at expected frequencies after further breeding. The homozygotes appeared normal, although no class I antigens could be detected on their cells and the animals are grossly deficient in CD4 - CD8 + T cells, which normally mediate cytotoxic T cell function.
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Citations
Cites
An Fc receptor structurally related to MHC class I antigens
Simister, N. E., & Mostov, K. E. (1989) · Nature · doi:10.1038/337184a0 · Cited by 729
Cited by
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944
Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896
A guide to antigen processing and presentation
Pishesha, N., Harmand, T. J., & Ploegh, H. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00707-2 · Cited by 805
Metadata
- Authors
- Koller, B. H., Marrack, P., Kappler, J. W., & Smithies, O.
- Venue
- Science
- Published
- 1990-06-08
- Volume
- 248
- Issue
- 4960
- Pages
- 1227-1230
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010315866
- Cited by
- 881
- References
- 1
- FWCI
- 24.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koller, B. H., Marrack, P., Kappler, J. W., & Smithies, O. (1990). Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells. Science. https://doi.org/10.1126/science.2112266
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
