The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
Open accessAbstract
The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infection and by double-stranded (ds)RNA. This activation results not only in increased antigen presentation and T cell stimulatory capacity, but also in resistance to the cytopathic effect of the virus, mediated by the production of type I interferon, and upregulation of MxA. Because dsRNA stimulates both maturation and resistance, DCs can serve as altruistic antigen-presenting cells capable of sustaining viral antigen production while acquiring the capacity to trigger naive T cells and drive polarized T helper cell type 1 responses.
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Cites
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
Cited by
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,207
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025
Vaccine adjuvants: mechanisms and platforms
Zhao, T., Cai, Y., Jiang, Y., He, X., Wei, Y., Yu, Y., & Tian, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01557-7 · Cited by 1,020
Jarrossay, D., Napolitani, G., Colonna, M., Sallusto, F., & Lanzavecchia, A. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200111)31:11<3388::aid-immu3388>3.0.co;2-q · Cited by 788
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Metadata
- Authors
- Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I., & Lanzavecchia, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-03-01
- Volume
- 189
- Issue
- 5
- Pages
- 821-829
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2139620037
- Cited by
- 709
- References
- 1
- FWCI
- 24.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Cella, M., Salio, M., Sakakibara, Y., Langen, H., Julkunen, I., & Lanzavecchia, A. (1999). Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.189.5.821
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