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Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations
Open accessAbstract
The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity.
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Citations
Cited by
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
The molecular architecture of the TNF superfamily
Bodmer, J.-L., Schneider, P., & Tschopp, J. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01995-8 · Cited by 916
Self-citationThien, M., Phan, T. G., Gardam, S., Amesbury, M., Basten, A., Mackay, F., & Brink, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.010 · Cited by 746
Self-citationGerminal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity
Elsner, R. A., & Shlomchik, M. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.006 · Cited by 526
Stohl, W., Metyas, S., Tan, S., Cheema, G. S., Oamar, B., Xu, D., Roschke, V., Wu, Y., Baker, K. P., & Hilbert, D. M. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11354 · Cited by 503
Metadata
- Authors
- Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J., & Browning, J. L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-12-06
- Volume
- 190
- Issue
- 11
- Pages
- 1697-1710
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1989279522
- Cited by
- 1,480
- References
- 0
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J., & Browning, J. L. (1999). Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.190.11.1697
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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