The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamin 2 Is Required for Phagocytosis in Macrophages
Open accessAbstract
Cells internalize soluble ligands through endocytosis and large particles through actin-based phagocytosis. The dynamin family of GTPases mediates the scission of endocytic vesicles from the plasma membrane. We report here that dynamin 2, a ubiquitously expressed dynamin isoform, has a role in phagocytosis in macrophages. Dynamin 2 is enriched on early phagosomes, and expression of a dominant-negative mutant of dynamin 2 significantly inhibits particle internalization at the stage of membrane extension around the particle. This arrest in phagocytosis resembles that seen with inhibitors of phosphoinositide 3-kinase (PI3K), and inhibition of PI3K prevents the recruitment of dynamin to the site of particle binding. Although expression of mutant dynamin in macrophages inhibited particle internalization, it had no effect on the production of inflammatory mediators elicited by particle binding.
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Araki, N., Johnson, M. T., & Swanson, J. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.5.1249 · Cited by 949 · cited 2×
“The phagocytic defect induced by dynK44A resembles that seen when PI3K is inhibited in macrophages (29, 30).”
BackgroundResultDynamin-mediated Internalization of Caveolae
Henley, J. R., Krueger, E. W. A., Oswald, B. J., & McNiven, M. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.85 · Cited by 767
Self-citation
Cited by
The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,377
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
Self-citationDynamin, a membrane-remodelling GTPase
Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
Cellular Internalization of Exosomes Occurs Through Phagocytosis
Feng, D., Zhao, W.-L., Ye, Y.-Y., Bai, X.-C., Liu, R.-Q., Chang, L.-F., Zhou, Q., & Sui, S.-F. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01041.x · Cited by 981
Phagocytosis and the actin cytoskeleton
May, R. C., & Machesky, L. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.6.1061 · Cited by 715
Metadata
- Authors
- Gold, E. S., Underhill, D. M., Morrissette, N. S., Guo, J., McNiven, M. A., & Aderem, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1999-12-20
- Volume
- 190
- Issue
- 12
- Pages
- 1849-1856
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2003959866
- Cited by
- 286
- References
- 2
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Gold, E. S., Underhill, D. M., Morrissette, N. S., Guo, J., McNiven, M. A., & Aderem, A. (1999). Dynamin 2 Is Required for Phagocytosis in Macrophages. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.190.12.1849
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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