Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo
Open accessAbstract
Posttranslational modification of peptide antigens has been shown to alter the ability of T cells to recognize major histocompatibility complex (MHC) class I–restricted peptides. However, the existence and origin of naturally processed phosphorylated peptides presented by MHC class I molecules have not been explored. By using mass spectrometry, significant numbers of naturally processed phosphorylated peptides were detected in association with several human MHC class I molecules. In addition, CD8+ T cells could be generated that specifically recognized a phosphorylated epitope. Thus, phosphorylated peptides are part of the repertoire of antigens available for recognition by T cells in vivo.
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Present yourself! by MHC class I and MHC class II molecules
Rock, K. L., Reits, E., & Neefjes, J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.08.010 · Cited by 814 · see citing works
- Authors
- Zarling, A. L., Ficarro, S. B., White, F. M., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H.
- Affiliations
- University of Virginia (US)
- aBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2000-12-18
- Volume
- 192
- Issue
- 12
- Pages
- 1755-1762
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2213507
- OpenAlex
- W2163955038
- Cited by
- 213
- References
- 0
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 18 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (T32CA009109, CA-09109)
- National Institute of Allergy and Infectious Diseases (R37AI033993, AI20963, R01AI020963, R01AI033993, R37AI020963, AI-33993)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- phosphopeptides, MHC class I, antigen processing, peptide presentation, post-translational modification, CD8+ T cells, T cell epitopes
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Antigens, Cell Line, HLA Antigens, Humans, Interferon-gamma, Mice, Inbred C57BL, Phosphopeptides, Mass Spectrometry, Histocompatibility Antigens Class I, Cytokines, Antigen Presentation, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Mice
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