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Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid from Staphylococcus aureus
Open accessAbstract
Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus aureus, the clinically most frequent Gram-positive pathogen, was inactive after purification. Here, a novel isolation procedure to prepare pure (>99%) biologically active LTA, allowing the first structural analysis by nuclear magnetic resonance and mass spectrometry, is described. A comparison with LTA purified by standard techniques revealed that alanine substituents are lost during standard purification, resulting in attenuated cytokine induction activity. In line with this finding, hydrolysis of alanine substituents of active LTA decimated cytokine induction. LTA represents a major immunostimulatory component of S. aureus.
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Citations
Cited by
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
Schröder, N. W. J., Morath, S., Alexander, C., Hamann, L., Hartung, T., Zähringer, U., Göbel, U. B., Weber, J. R., & Schumann, R. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212829200 · Cited by 641
Self-citationFernandez, E. M., Valenti, V., Rockel, C., Hermann, C., Pot, B., Boneca, I. G., & Grangette, C. (2011) · Gut · doi:10.1136/gut.2010.232918 · Cited by 376
Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes
Warszawska, J. M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67911 · Cited by 148
Popov, A., Abdullah, Z., Wickenhauser, C., Saric, T., Driesen, J., Hanisch, F.-G., Domann, E., Raven, E. L., Dehus, O., Hermann, C., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28996 · Cited by 133
Metadata
- Authors
- Morath, S., Geyer, A., & Hartung, T.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-02-05
- Volume
- 193
- Issue
- 3
- Pages
- 393-398
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2168452238
- Cited by
- 469
- References
- 0
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Morath, S., Geyer, A., & Hartung, T. (2001). Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid from Staphylococcus aureus. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.193.3.393
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
