The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis
Open accessAbstract
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4+ myelin-specific T cells. The role of CD8+ myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8+ T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8+ T cell–mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4+ T cell–mediated EAE. These data suggest that myelin-specific CD8+ T cells could function as effector cells in the pathogenesis of MS.
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Regulatory T Cells in Autoimmmunity
Shevach, E. M. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.423 · Cited by 1,236
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Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
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Cited by
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Three or more routes for leukocyte migration into the central nervous system
Ransohoff, R. M., Kivisäkk, P., & Kidd, G. (2003) · Nature Reviews Immunology · doi:10.1038/nri1130 · Cited by 1,052
Oligodendrocytes: biology and pathology
Bradl, M., & Lassmann, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0601-5 · Cited by 933
Metadata
- Authors
- Huseby, E. S., Liggitt, D., Brabb, T., Schnabel, B., Öhlén, C., & Goverman, J.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-09-03
- Volume
- 194
- Issue
- 5
- Pages
- 669-676
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2131851074
- Cited by
- 659
- References
- 41
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huseby, E. S., Liggitt, D., Brabb, T., Schnabel, B., Öhlén, C., & Goverman, J. (2001). A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.194.5.669
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
