Cited by 1,052Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsCell Adhesion Molecules Research

Three or more routes for leukocyte migration into the central nervous system

Ransohoff, Richard M., Kivisäkk, Pia, Kidd, Grahame·2003·Nature Reviews Immunology

Abstract

Leukocyte migration into and through tissues is fundamental to normal physiology, immunopathology and host defence. Leukocyte entry into the central nervous system (CNS) is restricted, in part, because of the blood-brain barrier (BBB). During the past decade, crucial components that are involved in the process of leukocyte migration have been identified and progress has been made in understanding the mechanisms of neuroinflammatory reactions. In this review, present knowledge of the trafficking determinants that guide the migration of leukocytes is superimposed onto the vascular and compartmental anatomy of the CNS. We discuss three distinct routes for leukocytes to enter the CNS and consider how different populations of leukocytes use trafficking signals to gain entry.

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Crossref · 10.1038/nri1130

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  • Leukocyte recruitment to the CNS is a multistep process regulated through expression of adherent surface molecules on leukocytes and endothelial cells.

    “Leukocyte recruitment to the CNS is a multistep process that is regulated through expression of adherent surface molecules on leukocytes and endothelial cells (Ransohoff et al, 2003).”

    From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Ransohoff et al, 2003

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Authors
Ransohoff, R. M., Kivisäkk, P., & Kidd, G.
Affiliations
Cleveland Clinic (US)
Corresponding author
Ransohoff, Richard M.
Venue
Nature Reviews Immunology
Published
2003-07
Volume
3
Issue
7
Pages
569-581
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W1977899668
Cited by
1,052
References
123
Citations by year
2026: 12 · 2025: 26 · 2024: 33 · 2023: 36 · 2022: 36 · 2021: 45 · 2020: 36 · 2019: 32 · 2018: 43 · 2017: 55 · 2016: 47 · 2015: 46 · 2014: 73 · 2013: 64 · 2012: 60
FWCI
5.43
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
leukocyte migration, central nervous system, blood-brain barrier, neuroinflammation, chemokines, immune privilege
MeSH terms
Animals, Cell Movement, Central Nervous System, Cerebrospinal Fluid, Encephalomyelitis, Autoimmune, Experimental, Humans, Immunologic Surveillance, Killer Cells, Natural, Lymphocytes, Neutrophils, Phagocytes, Spinal Cord, Receptors, Antigen, T-Cell, gamma-delta, CD8-Positive T-Lymphocytes

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