The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
A Natural Killer T (NKT) Cell Developmental Pathway Involving a Thymus-dependent NK1.1−CD4+ CD1d-dependent Precursor Stage
Open accessAbstract
The development of CD1d-dependent natural killer T (NKT) cells is poorly understood. We have used both CD1d/α-galactosylceramide (CD1d/αGC) tetramers and anti-NK1.1 to investigate NKT cell development in vitro and in vivo. Confirming the thymus-dependence of these cells, we show that CD1d/αGC tetramer-binding NKT cells, including NK1.1+ and NK1.1− subsets, develop in fetal thymus organ culture (FTOC) and are completely absent in nude mice. Ontogenically, CD1d/αGC tetramer-binding NKT cells first appear in the thymus, at day 5 after birth, as CD4+CD8−NK1.1−cells. NK1.1+ NKT cells, including CD4+ and CD4−CD8− subsets, appeared at days 7–8 but remained a minor subset until at least 3 wk of age. Using intrathymic transfer experiments, CD4+NK1.1− NKT cells gave rise to NK1.1+ NKT cells (including CD4+ and CD4− subsets), but not vice-versa. This maturation step was not required for NKT cells to migrate to other tissues, as NK1.1− NKT cells were detected in liver and spleen as early as day 8 after birth, and the majority of NKT cells among recent thymic emigrants (RTE) were NK1.1−. Further elucidation of this NKT cell developmental pathway should prove to be invaluable for studying the mechanisms that regulate the development of these cells.
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Cites
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
Bendelac, A., Rivera, M. N., Park, S.-H., & Roark, J. H. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.535 · Cited by 1,326
Lantz, O., & Bendelac, A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,057
Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
Matsuda, J. L., Naidenko, O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.-R., Koezuka, Y., & Kronenberg, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.741 · Cited by 887
NKT cells: facts, functions and fallacies
Godfrey, D. I., Hammond, K. J. L., Poulton, L. D., Smyth, M. J., & Baxter, A. G. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01735-7 · Cited by 858
Self-citationDifferential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells
Smyth, M. J., Thia, K. Y. T., Street, S. E. A., Cretney, E., Trapani, J. A., Taniguchi, M., Kawano, T., Pelikan, S. B., Crowe, N. Y., & Godfrey, D. I. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.4.661 · Cited by 829
Self-citationNKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
Terabe, M., Matsui, S., Noben-Trauth, N., Chen, H., Watson, C., Donaldson, D. D., Carbone, D. P., Paul, W. E., & Berzofsky, J. A. (2000) · Nature Immunology · doi:10.1038/82771 · Cited by 699
Scollay, R. G., Butcher, E. C., & Weissman, I. L. (1980) · European Journal of Immunology · doi:10.1002/eji.1830100310 · Cited by 557
In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers
Benlagha, K., Weiss, A., Beavis, A., Teyton, L., & Bendelac, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.11.1895 · Cited by 556
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.
Bendelac, A. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.6.2091 · Cited by 530
Cited by
T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells
Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P. J., Biron, C. A., Gapin, L., & Glimcher, L. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00076-7 · Cited by 722
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Self-citationTissue-specific functions of invariant natural killer T cells
Crosby, C. M., & Kronenberg, M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0034-2 · Cited by 367
De Santo, C., Arscott, R., Booth, S., Karydis, I., Jones, M., Asher, R., Salio, M., Middleton, M., & Cerundolo, V. (2010) · Nature Immunology · doi:10.1038/ni.1942 · Cited by 304
Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150
Metadata
- Authors
- Pellicci, D. G., Hammond, K. J. L., Uldrich, A. P., Baxter, A. G., Smyth, M. J., & Godfrey, D. I.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-03-25
- Volume
- 195
- Issue
- 7
- Pages
- 835-844
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2148219135
- Cited by
- 371
- References
- 49
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pellicci, D. G., Hammond, K. J. L., Uldrich, A. P., Baxter, A. G., Smyth, M. J., & Godfrey, D. I. (2002). A Natural Killer T (NKT) Cell Developmental Pathway Involving a Thymus-dependent NK1.1−CD4+ CD1d-dependent Precursor Stage. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20011544
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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