The DOI matches its Crossref record.
Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice
Abstract
We have used intrathymic injection of fluorescein isothiocyanate to label thymocytes in situ. The method gives random labeling of the thymocyte population and so can be used to quantitate the extent of migration of cells from the thymus to the periphery. Migrant cells can be visualized in frozen sections or cell suspensions of peripheral organs by their fluorescence. Our data show that in young adults, about 1% of thymocytes leave the thymus per day. Since the bulk of thymocytes turn over every 5 to 7 days, this indicates that the vast majority (95%) of thyrnocytes die within the thymus. Cells that do leave the thymus, go mainly to the T areas of lymph nodes, spleen and Peyer's patches. Migrants are extremely rare in bone marrow, gut and liver. Migration is about the same in neonates as in adults relative to the size of the thymus, but is considerably lower in older animals where it is only about 0.1% of thymocytes per day at the age of six months.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 31
- 10.1016/S0140-6736(61)90693-6 · DOI · Paper page
- 10.1016/0012-1606(61)90051-3 · DOI
- Le Douarin N. M., 1978, Cold Spring Harbor Conferences on Cell Proliferation, 5, 5
- 10.1111/j.1600-065X.1978.tb00264.x · DOI · Paper page
- Rouse R. V., 1979, J. Immunol., 122, 2508, 10.4049/jimmunol.122.6.2508 · doi:10.4049/jimmunol.122.6.2508
- 10.1159/000313401 · doi:10.1159/000313401
- 10.1084/jem.126.2.291 · DOI · Paper page
- 10.1038/bjc.1961.38 · doi:10.1038/bjc.1961.38
- 10.1002/eji.1830020109 · doi:10.1002/eji.1830020109
- 10.1007/978-1-4615-9011-8_15 · doi:10.1007/978-1-4615-9011-8_15
- 10.1111/j.1749-6632.1964.tb34715.x · doi:10.1111/j.1749-6632.1964.tb34715.x
- McPhee D. Pye J.andShortman K. Thymus1979 in press.
- Michalke W. D., 1969, Blood, 33, 541, 10.1182/blood.V33.4.541.541 · doi:10.1182/blood.v33.4.541.541
- Sainte‐Marie G., 1971, Rev. Can. Biol., 30, 51
- 10.1084/jem.123.3.559 · doi:10.1084/jem.123.3.559
- Poste M. E., 1973, Immunology, 24, 691
- 10.1084/jem.137.2.504 · doi:10.1084/jem.137.2.504
- Gutman G. A., 1972, Immunology, 23, 464
- 10.1038/276079a0 · doi:10.1038/276079a0
- 10.1063/1.1685647 · DOI · Paper page
- 10.1007/978-1-4615-9101-6_11 · doi:10.1007/978-1-4615-9101-6_11
- Russell E. S., 1966, The Biology of the Laboratory Mouse, 351
- 10.1038/icb.1963.53 · doi:10.1038/icb.1963.53
- 10.1152/ajplegacy.1968.215.2.353 · DOI · Paper page
- 10.1038/bjc.1972.33 · DOI · Paper page
- 10.1007/978-3-642-46044-9 · DOI
- 10.1038/newbio229182a0 · doi:10.1038/newbio229182a0
- Weissman I. L., 1975, Isr. J. Med. Sci., 11, 1267
- 10.1084/jem.135.4.907 · doi:10.1084/jem.135.4.907
- Weissman I. L., 1976, Immunol‐Aspects of the Spleen, 77
- Friedberg S. H., 1974, J. Immunol., 113, 1477, 10.4049/jimmunol.113.5.1477 · doi:10.4049/jimmunol.113.5.1477
Cited by
Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979
The aging immune system: primer and prospectus
Miller, R. A. (1996) · Science · doi:10.1126/science.273.5271.70 · Cited by 1,165
Turnover of naive- and memory-phenotype T cells.
Tough, D. F., & Sprent, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1127 · Cited by 869
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834
Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade
Sutherland, J. S., Goldberg, G. L., Hammett, M. V., Uldrich, A. P., Berzins, S. P., Heng, T. S., Blazar, B. R., Millar, J. L., Malin, M. A., Chidgey, A. P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2741 · Cited by 486
Metadata
- Authors
- Scollay, R. G., Butcher, E. C., & Weissman, I. L.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1980-03
- Volume
- 10
- Issue
- 3
- Pages
- 210-218
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2079826943
- Cited by
- 557
- References
- 0
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice. https://app.cochat.ai/papers/10.1002/eji.1830100310
- The paper
- Scollay, R. G., Butcher, E. C., & Weissman, I. L. (1980). Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice. European Journal of Immunology. https://doi.org/10.1002/eji.1830100310
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
