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Identification of Regulatory T Cells in Tolerated Allografts
Open accessAbstract
Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4+ T cells, which mediate this form of “dominant” tolerance, can be isolated from spleens of tolerant animals. To determine whether there were any extra-lymphoid sites that might harbor regulatory T cells we sought their presence in tolerated skin allografts and in normal skin. When tolerated skin grafts are retransplanted onto T cell–depleted hosts, graft-infiltrating T cells exit the graft and recolonize the new host. These colonizing T cells can be shown to contain members with regulatory function, as they can prevent nontolerant lymphocytes from rejecting fresh skin allografts, without hindrance of rejection of third party skin. Our results suggest that T cell suppression of graft rejection is an active process that operates beyond secondary lymphoid tissue, and involves the persistent presence of regulatory T cells at the site of the tolerated transplant.
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Cited by
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Lu, L.-F., Lind, E. F., Gondek, D. C., Bennett, K. A., Gleeson, M. W., Pino-Lagos, K., Scott, Z. A., Coyle, A. J., Reed, J. L., Van Snick, J., et al. (2006) · Nature · doi:10.1038/nature05010 · Cited by 751
Quezada, S. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27745 · Cited by 700
Mechanism of cellular rejection in transplantation
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Coenen, J. J. A., Koenen, H. J. P. M., van Rijssen, E., Hilbrands, L. B., & Joosten, I. (2006) · Blood · doi:10.1182/blood-2005-07-3032 · Cited by 252
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Marino, J., Paster, J., & Benichou, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00582 · Cited by 221
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Self-citationFasL microgels induce immune acceptance of islet allografts in nonhuman primates
Lei, J., Coronel, M. M., Yolcu, E. S., Deng, H., Grimany-Nuno, O., Hunckler, M. D., Ulker, V., Yang, Z., Lee, K. M., Zhang, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm9881 · Cited by 77
Harnessing FOXP3+ regulatory T cells for transplantation tolerance
Waldmann, H., Hilbrands, R., Howie, D., & Cobbold, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67226 · Cited by 69
Self-citationDendritic Cells and T Cells in the Regulation of Cutaneous Immunity
Loser, K., & Beissert, S. (2007) · Advances in Dermatology · doi:10.1016/j.yadr.2007.07.014 · Cited by 52
Chutipongtanate, A., Prukviwat, S., Pongsakul, N., Srisala, S., Kamanee, N., Arpornsujaritkun, N., Gesprasert, G., Apiwattanakul, N., Hongeng, S., Ittichaikulthol, W., et al. (2020) · BMC Anesthesiology · doi:10.1186/s12871-020-01130-7 · Cited by 11
Metadata
- Authors
- Graca, L., Cobbold, S. P., & Waldmann, H.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-06-10
- Volume
- 195
- Issue
- 12
- Pages
- 1641-1646
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2104959557
- Cited by
- 560
- References
- 0
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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