The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches
Open accessAbstract
B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4−/− B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches.
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Citations
Cites
Lymphocyte Homing and Homeostasis
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Metadata
- Authors
- Okada, T., Ngo, V. N., Ekland, E. H., Förster, R., Lipp, M., Littman, D. R., & Cyster, J. G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-06-24
- Volume
- 196
- Issue
- 1
- Pages
- 65-75
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2166588660
- Cited by
- 512
- References
- 1
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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