The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Lymphocyte homing to the gut: attraction, adhesion, and commitment
Abstract
Summary: Lymphocytes continuously migrate from the blood into the intestine. Naive lymphocytes leave the blood through high endothelial venules in Peyer's patches. During the multistep extravasation cascade, they sequentially roll on, firmly adhere to, and transmigrate through the endothelial layer using multiple adhesion molecules and chemotactic signals. In the organized lymphoid tissues of the gut, lymphocytes can become activated, if they meet their cognate antigens transported to Peyer's patches through the gut epithelium. During activation and proliferation, the lymphocytes become imprinted by the local dendritic cells, so that after returning to systemic circulation via the efferent lymphatic vasculature, they preferentially home to lamina propria of the gut to execute their effector functions. In inflammation, the recirculation routes of lymphocytes are altered, and these may explain the pathogenesis of certain extra‐intestinal manifestations of gut infections and inflammatory bowel diseases. The increased knowledge on the mechanisms that regulate lymphocyte homing and imprinting has clear applicability in designing more effective vaccination regimens. A detailed understanding of the mucosal homing has recently led to the development of the first successful anti‐adhesive therapeutics in human.
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“The α 4 + β 7 + T cell subset has been shown to home to the gut, although no significant disorder affecting the gut was observed in our patients (50,51).”
From Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections (2012) · cites this paper as [51]
Citations
Cites
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Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 6,905
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Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
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Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
MANDALA, S. M., Hajdu, R., Bergstrom, J. D., Quackenbush, E. J., Xie, J., Milligan, J. A., Thornton, R. A., Shei, G.-J., Card, D., Keohane, C.-A., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,691
Retinoic acid imprints gut-homing specificity on T cells
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Research works printed but not linked: 1
- Lindenboom K, G. B. Millenium Pharmaceuticals Anounces Phase II Data for MLN‐02 in Crohn's Disease.
Cited by
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1767 · Cited by 1,079
Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention
Gorfu, G., Rivera-Nieves, J., & Ley, K. (2009) · Current Molecular Medicine · doi:10.2174/156652409789105525 · Cited by 292
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections
Crequer, A., Troeger, A., Patin, E., Ma, C. S., Picard, C., Pedergnana, V., Fieschi, C., Lim, A., Abhyankar, A., Gineau, L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62949 · Cited by 159
The human intestinal B-cell response
Spencer, J., & Sollid, L. M. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.59 · Cited by 126
Metadata
- Authors
- Salmi, M., & Jalkanen, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2005-07-28
- Volume
- 206
- Issue
- 1
- Pages
- 100-113
- ISSN
- 0105-2896
- 1600-065X
- Cited by
- 103
- References
- 127
- Language
- en
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- Salmi, M., & Jalkanen, S. (2005). Lymphocyte homing to the gut: attraction, adhesion, and commitment. Immunological Reviews. https://doi.org/10.1111/j.0105-2896.2005.00285.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
