The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
NadA, a Novel Vaccine Candidate of Neisseria meningitidis
Open accessAbstract
Neisseria meningitidis is a human pathogen, which, in spite of antibiotic therapy, is still a major cause of mortality due to sepsis and meningitis. Here we describe NadA, a novel surface antigen of N. meningitidis that is present in 52 out of 53 strains of hypervirulent lineages electrophoretic types (ET) ET37, ET5, and cluster A4. The gene is absent in the hypervirulent lineage III, in N. gonorrhoeae and in the commensal species N. lactamica and N. cinerea. The guanine/cytosine content, lower than the chromosome, suggests acquisition by horizontal gene transfer and subsequent limited evolution to generate three well-conserved alleles. NadA has a predicted molecular structure strikingly similar to a novel class of adhesins (YadA and UspA2), forms high molecular weight oligomers, and binds to epithelial cells in vitro supporting the hypothesis that NadA is important for host cell interaction. NadA induces strong bactericidal antibodies and is protective in the infant rat model suggesting that this protein may represent a novel antigen for a vaccine able to control meningococcal disease caused by three hypervirulent lineages.
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Cites
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Self-citationVaccine Potential of the Neisseria meningitidis 2086 Lipoprotein
Fletcher, L. D., Bernfield, L., Barniak, V., Farley, J. E., Howell, A., Knauf, M., Ooi, P., Smith, R. P., Weise, P., Wetherell, M., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2088-2100.2004 · Cited by 332
A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers
Coureuil, M., Lécuyer, H., Bourdoulous, S., & Nassif, X. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.178 · Cited by 299
Metadata
- Authors
- Comanducci, M., Bambini, S., Brunelli, B., Adu-Bobie, J., Aricò, B., Capecchi, B., Giuliani, M. M., Masignani, V., Santini, L., Savino, S., Granoff, D. M., Caugant, D. A., Pizza, M., Rappuoli, R., & Mora, M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2002-05-28
- Volume
- 195
- Issue
- 11
- Pages
- 1445-1454
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2147483877
- Cited by
- 351
- References
- 34
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Comanducci, M., Bambini, S., Brunelli, B., Adu-Bobie, J., Aricò, B., Capecchi, B., Giuliani, M. M., Masignani, V., Santini, L., Savino, S., Granoff, D. M., Caugant, D. A., Pizza, M., Rappuoli, R., & Mora, M. (2002). NadA, a Novel Vaccine Candidate of Neisseria meningitidis. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20020407
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