The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Vaccination against Neisseria meningitidis Using Three Variants of the Lipoprotein GNA1870
Open accessAbstract
Sepsis and meningitis caused by serogroup B meningococcus are devastating diseases of infants and young adults, which cannot yet be prevented by vaccination. By genome mining, we discovered GNA1870, a new surface-exposed lipoprotein of Neisseria meningitidis that induces high levels of bactericidal antibodies. The antigen is expressed by all strains of N. meningitidis tested. Sequencing of the gene in 71 strains representative of the genetic and geographic diversity of the N. meningitidis population, showed that the protein can be divided into three variants. Conservation within each variant ranges between 91.6 to 100%, while between the variants the conservation can be as low as 62.8%. The level of expression varies between strains, which can be classified as high, intermediate, and low expressors. Antibodies against a recombinant form of the protein elicit complement-mediated killing of the strains that carry the same variant and induce passive protection in the infant rat model. Bactericidal titers are highest against those strains expressing high yields of the protein; however, even the very low expressors are efficiently killed. The novel antigen is a top candidate for the development of a new vaccine against meningococcus.
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Cites
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Self-citationComplete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
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Self-citationHUMAN IMMUNITY TO THE MENINGOCOCCUS
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Cited by
Lipoproteins of Bacterial Pathogens
Kovacs-Simon, A., Titball, R. W., & Michell, S. L. (2011) · Infection and Immunity · doi:10.1128/iai.00682-10 · Cited by 440
Vaccine Potential of the Neisseria meningitidis 2086 Lipoprotein
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Structural vaccinology starts to deliver
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Self-citationHijacking Factor H for Complement Immune Evasion
Moore, S. R., Menon, S. S., Cortes, C., & Ferreira, V. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.602277 · Cited by 83
Emerging experience with meningococcal serogroup B protein vaccines
Toneatto, D., Pizza, M., Masignani, V., & Rappuoli, R. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1308828 · Cited by 67
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Metadata
- Authors
- Masignani, V., Comanducci, M., Giuliani, M. M., Bambini, S., Adu-Bobie, J., Aricò, B., Brunelli, B., Pieri, A., Santini, L., Savino, S., Serruto, D., Litt, D., Kroll, S., Welsch, J. A., Granoff, D. M., Rappuoli, R., & Pizza, M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-03-17
- Volume
- 197
- Issue
- 6
- Pages
- 789-799
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1975355256
- Cited by
- 395
- References
- 32
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Masignani, V., Comanducci, M., Giuliani, M. M., Bambini, S., Adu-Bobie, J., Aricò, B., Brunelli, B., Pieri, A., Santini, L., Savino, S., Serruto, D., Litt, D., Kroll, S., Welsch, J. A., Granoff, D. M., Rappuoli, R., & Pizza, M. (2003). Vaccination against Neisseria meningitidis Using Three Variants of the Lipoprotein GNA1870. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20021911
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