Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

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Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

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Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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Anti-Nuclear Antibody Production and Autoimmunity in Transgenic Mice That Overexpress the Transcription Factor Bright

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De Novo Gain‐Of‐Function Variations in LYN Associated With an Early‐Onset Systemic Autoinflammatory Disorder

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Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS

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The dualistic role of Lyn tyrosine kinase in immune cell signaling: implications for systemic lupus erythematosus

L’Estrange-Stranieri, E., Gottschalk, T. A., Wright, M. D., & Hibbs, M. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395427 · Cited by 19

Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease

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Toll-like receptor 9 in murine lupus: More friend than foe!

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Src Tail Phosphorylation Is Limited by Structural Changes in the Regulatory Tyrosine Kinase Csk

Lieser, S. A., Shaffer, J., & Adams, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607824200 · Cited by 17

Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis

Sato, S., Fujimoto, M., Hasegawa, M., Takehara, K., & Tedder, T. F. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.01.009 · Cited by 17

B cells biology in systemic lupus erythematosus—from bench to bedside

Zhao, L., Ye, Y., & Zhang, X. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4953-x · Cited by 16

Constitutive activation of Lyn kinase enhances BCR responsiveness, but not the development of CLL in Eµ-TCL1 mice

Kohlhas, V., Hallek, M. J., & Nguyen, P. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002584 · Cited by 16

Structural basis for the inhibitor recognition of human Lyn kinase domain

Miyano, N., Kinoshita, T., Nakai, R., Kirii, Y., Yokota, K., & Tada, T. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.10.038 · Cited by 15

FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells

Pauls, S. D., Ray, A., Hou, S., Vaughan, A. T., Cragg, M. S., & Marshall, A. J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600105 · Cited by 16

Treatment with TNFα blockers induces phenotypical and functional aberrations in peripheral B cells

Karampetsou, M. P., Andonopoulos, A. P., & Liossis, S. C. (2011) · Clinical Immunology · doi:10.1016/j.clim.2011.01.012 · Cited by 13

Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein

Potůčková, L., Dráberová, L., Hálová, I., Paulenda, T., & Dráber, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01771 · Cited by 13

Molecular abnormalities of the B cell in systemic lupus erythematosus are candidates for functional inhibition treatments

Liossis, S. C., & Μελισσαρόπουλος, Κ. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.894976 · Cited by 13

GENES AND GENETICS OF MURINE LUPUS

Kono, D. H., Baccalà, R., & Theofilopoulos, A. N. (2004) · Elsevier eBooks · doi:10.1016/b9-78-012433-9/01950-0119 · Cited by 13

Silencing and activating anergic B cells*

Tanaka, S., Ise, W., Baba, Y., & Kurosaki, T. (2021) · Immunological Reviews · doi:10.1111/imr.13053 · Cited by 12

The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity

Zikherman, J., Parameswaran, R., Hermiston, M. L., & Weiss, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202928 · Cited by 12

Does B Cell Receptor Signaling in Chronic Lymphocytic Leukaemia Cells Differ from That in Other B Cell Types?

Slupsky, J. R. (2014) · Scientifica · doi:10.1155/2014/208928 · Cited by 15

Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer

Tsantikos, E., Gottschalk, T. A., L’Estrange-Stranieri, E., O’Brien, C. A., Raftery, A. L., Wickramasinghe, L. C., McQualter, J. L., Anderson, G. P., & Hibbs, M. L. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0463oc · Cited by 10

Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase

Kawakami, T., Xiao, W., Yasudo, H., & Kawakami, Y. (2011) · Advances in Biological Regulation · doi:10.1016/j.advenzreg.2011.09.003 · Cited by 11

Role of the Lyn tyrosine kinase in the development of autoimmune disease

Tsantikos, E., Gottschalk, T. A., Maxwell, M. J., & Hibbs, M. L. (2014) · International Journal of Clinical Rheumatology · doi:10.2217/ijr.14.44 · Cited by 9

No shortcuts: new findings reinforce why nuance is the rule in genetic autoinflammatory syndromes

Tsoukas, P., & Canna, S. (2017) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000422 · Cited by 8

Classifying microarray data with association rules

Antonie, L., & Bessonov, K. (2011) · ACM Symposium on Applied Computing · doi:10.1145/1982185.1982209 · Cited by 8

Genetics of Lupus in Mice

Kono, D. H., & Theofilopoulos, A. N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-374994-9.10004-x · Cited by 8

The Alternate Pathway for BCR Signaling Induced by IL-4 Requires Lyn Tyrosine Kinase

Khan, N., & Rothstein, T. L. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.10.002 · Cited by 7

Lymphoid hyperplasia and lymphoma in KSHV K1 transgenic mice.

Berkova, Z., Wang, S., Sehgal, L., Patel, K. P., Prakash, O., & Samaniego, F. (2015) · PubMed · doi:10.14670/hh-30.559 · Cited by 7

Targeting B-Cell Receptor Signaling in Leukemia and Lymphoma: How and Why?

Allen, J. C., Talab, F., & Slupsky, J. R. (2016) · International Journal of Hematologic Oncology · doi:10.2217/ijh-2016-0003 · Cited by 7

FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases

Stefanova, D., Olszewski, D., Glitscher, M., Bauer, M., Ferrarese, L., Wüst, D., Hildt, E., Greber, U., & Werner, S. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05502-x · Cited by 4

Multiplex Analysis of Src Family Kinase Signaling by Microbead Suspension Arrays

Campbell, M., Lie, W., Zhao, J., Hayes, D., Mistry, J., Kung, H.-J., Luciw, P. A., & Khan, I. (2010) · Assay and Drug Development Technologies · doi:10.1089/adt.2009.0255 · Cited by 6

Genetic variability associates with ancestry, age at disease onset, organ involvement and disease severity in juvenile-onset systemic lupus erythematosus

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Pentacyclic triterpenoid ursolic acid interferes with mast cell activation via a lipid-centric mechanism affecting FcεRI signalosome functions

Shaik, G. M., Dráberová, L., Cernohouzova, S., Tůmová, M., Bugajev, V., & Dráber, P. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102497 · Cited by 5

Animal Models: Systemic Autoimmune Diseases

Mizui, M., & Tsokos, G. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812102-3.00029-4 · Cited by 5

Decompartmentalizing target validation—thinking outside the pipeline boxes

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STAP ‐2 negatively regulates BCR ‐mediated B cell activation by recruiting tyrosine‐protein kinase CSK to LYN

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Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner

Lindstedt, A. J., Greene, J. T., Xu, Y., Williams, J. W., & Freedman, T. S. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf140 · Cited by 3

Integrated signaling and transcriptome analysis reveals Src family kinase individualities and novel pathways controlled by their constitutive activity

Κούτρας, Ν., Morfos, V., Konnaris, K., Kouvela, A., Shaukat, A., Stathopoulos, C., Stamatopoulou, V., & Nika, K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224520 · Cited by 3

B cell abnormalities and autoantibody production in systemic sclerosis

Sato, S. (2006) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.29.73 · Cited by 3

Avian leukosis virus subgroup J induces B cell anergy mediated by Lyn inhibited BCR signal transduction

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Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model

Tornillo, G., Warrington, L., Kendrick, H. D., Higgins, A. T., Hay, T., Beck, S., & Smalley, M. J. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050211 · Cited by 2

Animal Models of Autoimmune Disease

von Herrath, M., & Tsokos, G. C. (2006) · Elsevier eBooks · doi:10.1016/b978-012595961-2/50029-9 · Cited by 2

A dual-targeted nanoplatform with miR-155 inhibition and ROS clearance abilities for chronic nephritis therapy

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Biologically relevant association rules for classification of microarray data

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Genetics of Autoreactive B Cells

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Phenotypic and Functional Characteristics of the IgM-IgD+ Naive B Cell Population in SLE Patients

Kim, J. J. (2010) · TSpace (University of Toronto) · Cited by 1

Steady-state phosphorylation of SHIP1 by Lyn restricts macrophage activation in the absence of a phagocytic synapsePreprint

Senevirathne, S. E., Kanagy, W. K., Cattley, R. T., Swanson, W. L., Ramos, S. T., Nunez, M. G., Hawse, W. F., & Freedman, T. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.16.648985 · Cited by 1

Studies into the function and regulation of SHIP

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B cell receptor signaling in receptor editing and leukemia

Ramsey, L. B. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)

Crippled B Lymphocyte Signaling Checkpoints in Systemic Autoimmunity

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La ausencia de CD38 induce un fenotipo autoinmune en el ratón C57BL/6 CD38-/- de edad avanzada

Domínguez-Pantoja, M. (2014)

Receptor Signaling and Syk in the Initiation of B-Cell Antigen Nonredundant Roles of Src-Family Kinases

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of the Roles of Lyn and Fyn B Cell Antigen Receptor Signaling: Analysis A Computational Model for Early Events in

Barua, D., Hlavacek, W. S., & Lipniacki, T. (2012)

THE THIOREDOXIN TRX-1 REGULATES THE MAJOR OXIDATIVE STRESS RESPONSE TRANSCRIPTION FACTOR, SKN-1, IN CAENORHABDITIS ELEGANS

McCallum, K. C. (2016) · Digital Commons-TMC (Texas Medical Center)

Biochemical and Functional Characterization of Inhibitory Leukocyte Immune-Type Receptors in the Channel Catfish (Ictalurus punctatus)

Montgomery, B. C. (2013) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3n92m

Identification and validation of potential targets for the diagnosis and therapy of chronic lymphocytic leukaemia

Varghese, A. M. (2013) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Galectin-9 inhibits B cell receptor (BCR) signaling by regulating BCR organization and mobility

Cao, A. (2017) · TSpace (University of Toronto)

Animal Models

Mizui, M., & Tsokos, G. C. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00030-7

Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour modelPreprint

Tornillo, G., Warrington, L., Kendrick, H. D., Higgins, A. T., Hay, T., Beck, S., & Smalley, M. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.23.533973

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunityPreprint

Ono, C., Tanaka, S., Myouzen, K., Iwasaki, T., Ueda, M. T., Oda, Y., Yamamoto, K., Kochi, Y., & Baba, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549843

Betulinic Acid Potentiates Mast Cell Degranulation by Compromising Cell Membrane Integrity and Without Involving Fcεri Receptors

Shaik, G. M., & Khan, M. S. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2329990

Total, not isoform-specific, Lyn expression by macrophages promotes TLR activation and restricts proliferationPreprint

Lindstedt, A. J., Greene, J. T., & Freedman, T. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.663098

Examining the conditions associated with establishing plasma cell persistence

Mulder, J., Scrofani, J., Chheng, K., O’Donnell, K., Tarlinton, D. M., Robinson, M. J., & Ding, Z. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf149

Activation of B1 Cells

Catalán, D., & Ribeiro, C. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00234-9

Targeting SET to counteract Lyn activation demonstrates anti-cancer potential in diffuse large B-cell lymphoma

Chen, J.-L., Chu, P., Huang, C.-T., Wang, W., Chang, Y.-Y., Dai, M., & Liu, C. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01874-x

Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse

Senevirathne, S. E., Kanagy, W. K., Hemmila, C. R., Greene, J. T., Rajczewski, A. T., Cattley, R. T., Swanson, W. L., Ramos, S. T., Nunez, M. G., Jin, S., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkaf372

New roles of the Lyn tyrosine kinase in psoriasis development and cell death

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Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells

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BindingDB Entry 50030666: Structural basis for the inhibitor recognition of human Lyn kinase domain.

BindingDB (2010) · UC San Diego · doi:10.7270/q2tt4r1d

Regulation of B‐1 cell activation and its autoantibody production by Lyn kinase‐regulated signallings

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B Cell–Specific Loss of Lyn Kinase Leads to Autoimmunity

Lamagna, C., Hu, Y., DeFranco, A. L., & Lowell, C. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301979 · Cited by 143

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

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A Kinase-Dead Allele of Lyn Attenuates Autoimmune Disease Normally Associated with Lyn Deficiency

Verhagen, A. M., Wallace, M. E., Goradia, A., Jones, S. A., McQuilten, H. A., Metcalf, D., Collinge, J. E., Maxwell, M. J., Hibbs, M. L., Alexander, W. S., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803127 · Cited by 20

Reduced Dosage of Bruton’s Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn −/− Mice

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