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The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
Open accessAbstract
The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex–related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.
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“In health, this receptor is bound to albumin and has been found to prolong the half‐life of albumin while there is substantial cycling of serum albumin into and out of the cell,21”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [21]
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Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311
Fraker, P. J., & Speck, J. C. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91322-0 · Cited by 4,553
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
All About Albumin: Biochemistry, Genetics, and Medical Applications
Peters, T. (1995) · Thammasat University Digital Collections · Cited by 3,089
Monoclonal Antibodies: Principles and Practice
Goding, J. W. (1996) · Cited by 903
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
Koller, B. H., Marrack, P., Kappler, J. W., & Smithies, O. (1990) · Science · doi:10.1126/science.2112266 · Cited by 884
Waldmann, T. A., & Strober, W. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000385919 · Cited by 731
An Fc receptor structurally related to MHC class I antigens
Simister, N. E., & Mostov, K. E. (1989) · Nature · doi:10.1038/337184a0 · Cited by 729
Junghans, R. P., & Anderson, C. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5512 · Cited by 692
Self-citationThe transmission of passive immunity from mother to young
Brambell, F. W. R. (1970) · Cited by 616
Multiple Roles for the Major Histocompatibility Complex Class I– Related Receptor FcRn
Ghetie, V. F., & Ward, E. S. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.739 · Cited by 481
Abnormally short serum half‐lives of IgG in β2‐microglobulin‐deficient mice
Ghetie, V. F., Hubbard, J. G., Kim, J., Tsen, M. F., Lee, Y., & Ward, E. S. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260327 · Cited by 469
Comparative Genomics of the MHC
Flajnik, M. F., & Kasahara, M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00198-4 · Cited by 363
Leach, J. L., Sedmak, D. D., Osborne, J. M., Rahill, B., Lairmore, M. D., & Anderson, C. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.8.3317 · Cited by 348
Self-citationIncreased clearance of IgG in mice that lack β2‐microglobulin: possible protective role of FcRn
Israel, E. J., Wilsker, D. F., Hayes, K. C., Schoenfeld, D., & Simister, N. E. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-775.x · Cited by 334
Zhu, X., Meng, G., Dickinson, B. L., Li, X., Mizoguchi, E., Miao, L., Wang, Y., Robert, C., Wu, B., Smith, P. D., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3266 · Cited by 322
Estimation of Variance for Harmonic Mean Half-Lives
Lam, F. C., Hung, C. T., & Perrier, D. G. (1985) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600740229 · Cited by 300
West, A. P., & Björkman, P. J. (2000) · Biochemistry · doi:10.1021/bi000749m · Cited by 261
Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice
Borvák, J. (1998) · International Immunology · doi:10.1093/intimm/10.9.1289 · Cited by 254
Schultze, H. E., & Heremans, J. F. (1966) · Cited by 208
Finally! the Brambell receptor (FcRB)
Junghans, R. P. (1997) · Immunologic Research · doi:10.1007/bf02786322 · Cited by 205
Isolation and characterization of the Fc receptor from the fetal yolk sac of the rat.
Roberts, D. M., Guenthert, M., & Rodewald, R. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.5.1867 · Cited by 152
Raghavan, M., Chen, M. Y., Gastinel, L. N., & Björkman, P. J. (1994) · Immunity · doi:10.1016/1074-7613(94)90082-5 · Cited by 146
Bos, N. A., Kimura, H., Meeuwsen, C. G., Visser, H. D., Hazenberg, M. P., Wostmann, B. S., Pleasants, J. R., Benner, R., & Marcus, D. M. (1989) · European Journal of Immunology · doi:10.1002/eji.1830191223 · Cited by 137
Regulated Expression and Inhibitory Function of FcγRIIb in Human Monocytic Cells
Tridandapani, S., Siefker, K., Carter, J. E., Wewers, M. D., Anderson, C. L., & Teillaud, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110277200 · Cited by 135
Self-citationResistance of MHC class I-deficient mice to experimental systemic lupus erythematosus
Mozes, E., Kohn, L. D., Hakim, F. T., & Singer, D. S. (1993) · Science · doi:10.1126/science.8316860 · Cited by 107
Gastinel, L. N., Simister, N. E., & Björkman, P. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.638 · Cited by 98
THE BEHAVIOR OF I131‐LABELED PLASMA PROTEINS IN VIVO
McFarlane, A. S. (1957) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1957.tb35374.x · Cited by 93
Telleman, P., & Junghans, R. P. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00034.x · Cited by 91
Cormode, E. J., Lyster, D. M., & Israels, S. (1975) · The Journal of Pediatrics · doi:10.1016/s0022-3476(75)80215-0 · Cited by 85
Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin.
Mixter, P. F., Russell, J. Q., Durie, F. H., & Budd, R. C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.5.2063 · Cited by 77
Quantitative estimations of five classes of immunoglobulin in inbred mouse strains.
Natsuume-Sakai, S., Motonishi, K., & Migita, S. (1977) · PubMed · Cited by 74
Nature and metabolism of extracellular proteins
Schultze, H. E., & Heremans, J. F. (1966) · Elsevier eBooks · Cited by 63
Soltysik-Española, M., Klinzing, D. C., Pfarr, K. M., Burke, R. D., & Ernst, S. G. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1235 · Cited by 41
IgG in Murine Intestinal Secretions Aging Effect and Possible Physiological Role
Senda, S., Cheng, E. H., & Kawanishi, H. (1989) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1989.tb01097.x · Cited by 9
Albumin Catabolism in Hypoproteinaemic States Studied with 131I-Albumin
FREEMAN, T., & Gordon, A. H. (2015) · Proceedings of the International Society of Blood Transfusion · doi:10.1159/000384419 · Cited by 6
Flagged first, then by citations
Research works printed but not linked: 2
- 1969, Prog. Allergy., 13, 1
- 1977, Immunology., 32, 861
Cited by
Sorted by citations
IgG Subclasses and Allotypes: From Structure to Effector Functions
Vidarsson, G., Dekkers, G., & Rispens, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00520 · Cited by 2,667
FcRn: the neonatal Fc receptor comes of age
Roopenian, D. C., & Akilesh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2155 · Cited by 2,346
Self-citationSignaling Mechanisms Regulating Endothelial Permeability
Mehta, D., & Malik, A. B. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2005 · Cited by 1,754
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
The Discovery and Development of Liraglutide and Semaglutide
Knudsen, L. B., & Lau, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00155 · Cited by 970
Metadata
- Authors
- Chaudhury, C., Mehnaz, S., Robinson, J. M., Hayton, W. L., Pearl, D. K., Roopenian, D. C., & Anderson, C. L.
- Affiliations
- The Ohio State University (US)
- Jackson Laboratory (US)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-01-27
- Volume
- 197
- Issue
- 3
- Pages
- 315-322
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2193842
- OpenAlex
- W2127401827
- Cited by
- 640
- References
- 37
- Citations by year
- 2026: 27 · 2025: 39 · 2024: 35 · 2023: 29 · 2022: 40 · 2021: 50 · 2020: 33 · 2019: 34 · 2018: 41 · 2017: 28 · 2016: 31 · 2015: 29 · 2014: 35 · 2013: 29 · 2012: 30
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- Lupus Research Alliance
- National Institutes of Health
- National Cancer Institute (CA88053, R01CA088053)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-56597, R01DK056597)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD038764, HD-38764)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- neonatal Fc receptor, albumin, pH-dependent binding, plasma protein turnover, IgG half-life
- MeSH terms
- Animals, Cattle, Half-Life, Cricetinae, Hydrogen-Ion Concentration, Immunoglobulin G, Major Histocompatibility Complex, Mice, Inbred C57BL, Protein Binding, Receptors, Fc, Recombinant Proteins, Serum Albumin, Bovine, Histocompatibility Antigens Class I, CHO Cells, Mice, Knockout, Mice, Rats, In Vitro Techniques
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