Cited by 2,667Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

IgG Subclasses and Allotypes: From Structure to Effector Functions

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Vidarsson, Gestur, Dekkers, Gillian, Rispens, Theo·2014·Frontiers in Immunology

Abstract

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both IgG-Fc receptors (FcγR) and C1q. As a result, the different subclasses have different effector functions, both in terms of triggering FcγR-expressing cells, resulting in phagocytosis or antibody-dependent cell-mediated cytotoxicity, and activating complement. The Fc-regions also contain a binding epitope for the neonatal Fc receptor (FcRn), responsible for the extended half-life, placental transport, and bidirectional transport of IgG to mucosal surfaces. However, FcRn is also expressed in myeloid cells, where it participates in both phagocytosis and antigen presentation together with classical FcγR and complement. How these properties, IgG-polymorphisms and post-translational modification of the antibodies in the form of glycosylation, affect IgG-function will be the focus of the current review.

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Crossref · 10.3389/fimmu.2014.00520

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  • In one of the first studies, a shift of the peak levels of systemic IL-6 and TNF from nighttime to daytime was observed in 11 individuals with insomnia without concomitant mental disorders, compared with healthy age- and body-mass index-matched control participants.

    “a shift of the peak levels of systemic IL-6 and TNF from nighttime to daytime was observed in 11 individuals with insomnia without concomitant mental disorders, compared with healthy age- and body-mass index-matched control participants”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [565]

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  1. [86]de Lange G. Monoclonal Antibodies Against Human Immunoglobulin Allotypes. Ph.D. thesis, University of London, London (1988).

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Authors
Vidarsson, G., Dekkers, G., & Rispens, T.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Vidarsson, Gestur
Venue
Frontiers in Immunology
Published
2014-10-20
Volume
5
Pages
520-520
ISSN
1664-3224 (ISSN-L)
OpenAlex
W2169656611
Cited by
2,667
References
219
Citations by year
2026: 228 · 2025: 261 · 2024: 288 · 2023: 315 · 2022: 309 · 2021: 289 · 2020: 270 · 2019: 219 · 2018: 176 · 2017: 148 · 2016: 118 · 2015: 41
FWCI
15.92
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
IgG subclasses, IgG allotypes, hinge region, CH2 domain, Fc gamma receptor, C1q, antibody-dependent cellular cytotoxicity, phagocytosis, complement activation, neonatal Fc receptor, antibody half-life, placental transport, antibody glycosylation, antigen presentation

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