The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
Open accessAbstract
Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-γ gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes.
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Cites
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Cited by
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Lanier, L. L. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,769
Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Mattner, J., DeBord, K. L., Ismail, N., Goff, R. D., Cantu, C., Zhou, D., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., et al. (2005) · Nature · doi:10.1038/nature03408 · Cited by 1,121
Immune surveillance by the liver
Jenne, C. N., & Kubes, P. (2013) · Nature Immunology · doi:10.1038/ni.2691 · Cited by 1,047
Metadata
- Authors
- Stetson, D. B., Mohrs, M., Reinhardt, R. L., Baron, J. L., Wang, Z.-E., Gapin, L., Kronenberg, M., & Locksley, R. M.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-10-06
- Volume
- 198
- Issue
- 7
- Pages
- 1069-1076
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2148077170
- Cited by
- 617
- References
- 1
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Stetson, D. B., Mohrs, M., Reinhardt, R. L., Baron, J. L., Wang, Z.-E., Gapin, L., Kronenberg, M., & Locksley, R. M. (2003). Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20030630
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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