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RETRACTED: KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells
Open accessAbstract
Primary effusion lymphomas (PELs) associated with infection by the Kaposi's sarcoma–associated herpesvirus (KSHV/HHV-8) have constitutive nuclear factor (NF)–κB activity that is essential for their survival, but the source of this activity is unknown. We report that viral FADD-like interleukin-1-β–converting enzyme [FLICE/caspase 8]-inhibitory protein (FLIP) activates NF-κB more potently than cellular FLIP in B cells and that it is largely responsible for NF-κB activation in latently infected PEL cells. Elimination of vFLIP production in PEL cells by RNA interference results in significantly decreased NF-κB activity, down-regulation of essential NF-κB–regulated cellular prosurvival factors, induction of apoptosis, and enhanced sensitivity to external apoptotic stimuli. vFLIP is the first virally encoded gene shown to be essential for the survival of naturally infected tumor cells.
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Cited by
Mechanisms of B-cell lymphoma pathogenesis
Küppers, R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1589 · Cited by 965
Bhutani, M., Polizzotto, M. N., Uldrick, T. S., & Yarchoan, R. (2015) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.12.027 · Cited by 155
Metadata
- Authors
- Guasparri, I., Keller, S. A., & Cesarman, E.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-04-05
- Volume
- 199
- Issue
- 7
- Pages
- 993-1003
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2123685397
- Cited by
- 324
- References
- 0
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- CoChat. (2026). Citation check: RETRACTED: KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells. https://app.cochat.ai/papers/10.1084/jem.20031467
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- Guasparri, I., Keller, S. A., & Cesarman, E. (2004). RETRACTED: KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20031467
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
