The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
Open accessAbstract
Plasma cells comprise a population of terminally differentiated B cells that are dependent on the transcriptional regulator B lymphocyte–induced maturation protein 1 (Blimp-1) for their development. We have introduced a gfp reporter into the Blimp-1 locus and shown that heterozygous mice express the green fluorescent protein in all antibody-secreting cells (ASCs) in vivo and in vitro. In vitro, these cells display considerable heterogeneity in surface phenotype, immunoglobulin secretion rate, and Blimp-1 expression levels. Importantly, analysis of in vivo ASCs induced by immunization reveals a developmental pathway in which increasing levels of Blimp-1 expression define developmental stages of plasma cell differentiation that have many phenotypic and molecular correlates. Thus, maturation from transient plasmablast to long-lived ASCs in bone marrow is predicated on quantitative increases in Blimp-1 expression.
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Cites
Plasma cell differentiation requires the transcription factor XBP-1
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A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements
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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
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Cited by
The generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3795 · Cited by 1,454
Self-citationHobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Mackay, L. K., Minnich, M., Kragten, N. A. M., Liao, Y., Nota, B., Seillet, C., Zaid, A., Man, K., Preston, S., Freestone, D., et al. (2016) · Science · doi:10.1126/science.aad2035 · Cited by 1,010
Self-citationTranscription factor IRF4 controls plasma cell differentiation and class-switch recombination
Klein, U., Casola, S., Cattoretti, G., Shen, Q., Lia, M., Mo, T., Ludwig, T., Rajewsky, K., & Dalla-Favera, R. (2006) · Nature Immunology · doi:10.1038/ni1357 · Cited by 801
Cretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, G. T., Smyth, G. K., Busslinger, M., Nutt, S. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2006 · Cited by 605
Self-citationSciammas, R., Shaffer, A. L., Schatz, J. H., Zhao, H., Staudt, L. M., & Singh, H. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.009 · Cited by 571
Metadata
- Authors
- Kallies, A., Hasbold, J., Tarlinton, D. M., Dietrich, W., Corcoran, L. M., Hodgkin, P. D., & Nutt, S. L.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-10-18
- Volume
- 200
- Issue
- 8
- Pages
- 967-977
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2101974006
- Cited by
- 531
- References
- 45
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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