Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
Abstract
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
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Pip-deficient animals develop normal numbers of B cells including λ-expressors but cannot undergo activation.
“Pip-deficient animals develop normal numbers of B cells (including λ-expressors) which cannot undergo activation”
From Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers (1999) · cites this paper as Mittrucker et al., 1997
IRF-4−/− mice have severe defects in B and T lymphocyte function.
“IRF-4 2 / 2 mice develop progressive generalized lymphadenopathy and have severe defects in B and T lymphocyte function. (65)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [65]
IRF-4−/− mice develop progressive generalized lymphadenopathy.
“IRF-4 2 / 2 mice develop progressive generalized lymphadenopathy and have severe defects in B and T lymphocyte function. (65)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [65]
Cites
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A. C., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,258 · see citing works
Self-citationInterleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. I., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,079 · see citing works
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843 · see citing works
Self-citationTanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491 · see citing works
Self-citationPip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447 · see citing works
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431 · see citing works
Self-citationBetz, A. G., Milstein, C., González‐Fernández, Á., Pannell, R., Larson, T., & Neuberger, M. S. (1994) · Cell · doi:10.1016/0092-8674(94)90316-6 · Cited by 379 · see citing works
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366 · see citing works
Transitional B cells are the target of negative selection in the B cell compartment.
Carsetti, R., Köhler, G., & Lamers, M. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2129 · Cited by 358 · see citing works
Interferon-Induced Antiviral Actions and Their Regulation
Sen, G. C., & Ransohoff, R. M. (1993) · Advances in virus research · doi:10.1016/s0065-3527(08)60083-4 · Cited by 334 · see citing works
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., & Taniguchi, T. (1996) · Nature · doi:10.1038/382816a0 · Cited by 324 · see citing works
Self-citationFunctional analysis of T lymphocyte subsets in antiviral host defense.
Leist, T. P., Cobbold, S. P., Waldmann, H., Aguet, M., & Zinkernagel, R. M. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.7.2278 · Cited by 233 · see citing works
Matsuyama, T., Grossman, A., Mittrücker, H.-W., Siderovski, D. P., Kiefer, F., Kawakami, T., Richardson, C. D., Taniguchi, T., Yoshinaga, S. K., & Mak, T. W. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2127 · Cited by 232 · see citing works
Self-citationKneitz, B., Herrmann, T., Yonehara, S., & Schimpl, A. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250925 · Cited by 229 · see citing works
Yamagata, T., Nishida, J., Tanaka, T., Sakai, R., Mitani, K., Yoshida, M., Taniguchi, T., Yazaki, Y., & Hirai, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1283 · Cited by 196 · see citing works
Peripheral lymphoid development and function in TCR mutant mice
Mombaerts, P., Mizoguchi, E., Ljunggren, H., lacomini, J., Ishikawa, H., Wang, L., Grusby, M. J., Gilmcher, L. H., Winn, H. J., Bhan, A. K., et al. (1994) · International Immunology · doi:10.1093/intimm/6.7.1061 · Cited by 96 · see citing works
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.
Benatar, T., Carsetti, R., Furlonger, C. L., Kamalia, N., Mak, T. W., & Paige, C. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.329 · Cited by 91 · see citing works
Self-citationThe importance of the 3′-enhancer region in immunoglobulinxgene expression
Meyer, K. B., Sharpe, M. J., Surani, M. A., & Neuberger, M. S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.19.5609 · Cited by 81 · see citing works
Mittrücker, H., Shahinian, A., Bouchard, D., Kündig, T. M., & Mak, T. W. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2481 · Cited by 77 · see citing works
Self-citationGrossman, A., Mittrücker, H.-W., Nicholl, J. K., Suzuki, A., Chung, S., Antonio, L., Suggs, S., Sutherland, G. R., Siderovski, D. P., & Mak, T. W. (1996) · Genomics · doi:10.1006/geno.1996.0547 · Cited by 76 · see citing works
Self-citationMoskophidis, D., & Lehmann-Grube, F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3291 · Cited by 55 · see citing works
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Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925 · see citing works
Honda, K., & Taniguchi, T. (2006) · Nature reviews. Immunology · doi:10.1038/nri1900 · Cited by 1,676 · see citing works
IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658 · see citing works
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Reimold, A., Iwakoshi, N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E., Friend, D., Grusby, M., Alt, F., & Glimcher, L. (2001) · Nature · doi:10.1038/35085509 · Cited by 1,371 · see citing works
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
Theofilopoulos, A. N., Baccalà, R., Beutler, B., & Kono, D. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115843 · Cited by 1,185 · see citing works
Davis, R. E., Brown, K. D., Siebenlist, U. K., & Staudt, L. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.12.1861 · Cited by 1,053 · see citing works
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T.-T., Corcoran, L., Treuting, P., Klein, U., & Rudensky, A. Y. (2009) · Nature · doi:10.1038/nature07674 · Cited by 958 · see citing works
Lin, R., Heylbroeck, C., Pitha, P. M., & Hiscott, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2986 · Cited by 915 · see citing works
Germinal centres: role in B-cell physiology and malignancy
Klein, U., & Dalla‐Favera, R. (2007) · Nature reviews. Immunology · doi:10.1038/nri2217 · Cited by 899 · see citing works
Regulation of plasma-cell development
Shelef, M. A., & Calame, K. L. (2005) · Nature reviews. Immunology · doi:10.1038/nri1572 · Cited by 881 · see citing works
Yoneyama, M., Suhara, W., Fukuhara, Y., Fukuda, M., Nishida, E., & Fujita, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1087 · Cited by 841 · see citing works
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
Klein, U., Casola, S. S., Cattoretti, G., Shen, Q. “., Lia, M., Mo, T., Ludwig, T. E., Rajewsky, K., & Dalla‐Favera, R. (2006) · Nature Immunology · doi:10.1038/ni1357 · Cited by 802 · see citing works
Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process
Hallek, M. J., Bergsagel, P. L., & Anderson, K. C. (1998) · Blood · doi:10.1182/blood.v91.1.3 · Cited by 747 · see citing works
IRF4 addiction in multiple myeloma
Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., et al. (2008) · Nature · doi:10.1038/nature07064 · Cited by 730 · see citing works
Ronco, L. V., Karpova, A. Y., Vidal, M., & Howley, P. M. (1998) · Genes & Development · doi:10.1101/gad.12.13.2061 · Cited by 631 · see citing works
The endoplasmic reticulum stress response in immunity and autoimmunity
Todd, D. J., Lee, A., & Glimcher, L. H. (2008) · Nature reviews. Immunology · doi:10.1038/nri2359 · Cited by 621 · see citing works
Transcriptional Control of Adipose Lipid Handling by IRF4
Eguchi, J., Wang, X., Yu, S., Kershaw, E. E., Chiu, P. C., Dushay, J. R., Estall, J. L., Klein, U., Maratos–Flier, E., & Rosen, E. D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.005 · Cited by 607 · see citing works
Cretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, G. T., Smyth, G. K., Busslinger, M., Nutt, S. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2006 · Cited by 605 · see citing works
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
Honjo, T., Kinoshita, K., & Muramatsu, M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.090501.112049 · Cited by 598 · see citing works
Interferon regulatory factors: the next generation
Mamane, Y., Heylbroeck, C., Génin, P., Algarté-Génin, M., Servant, M. J., Page, C. L., DeLuca, C., Kwon, H., Lin, R., & Hiscott, J. B. (1999) · Gene · doi:10.1016/s0378-1119(99)00262-0 · Cited by 570 · see citing works
Sciammas, R., Shaffer, A. L., Schatz, J. H., Zhao, H., Staudt, L. M., & Singh, H. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.009 · Cited by 564 · see citing works
Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.
Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S., Sakaguchi, S., Takeda, K., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.016 · Cited by 543 · see citing works
Vasanthakumar, A., Moro, K., Xin, A., Liao, Y., Gloury, R., Kawamoto, S., Fagarasan, S., Mielke, L. A., Afshar‐Sterle, S., Masters, S. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3085 · Cited by 556 · see citing works
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
Staudt, V., Bothur, E., Klein, M., Lingnau, K., Reuter, S., Grebe, N., Gerlitzki, B., Hoffmann, M., Ulges, A., Taube, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.014 · Cited by 554 · see citing works
Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
Kallies, A., Hasbold, J., Tarlinton, D. M., Dietrich, W., Corcoran, L. M., Hodgkin, P. D., & Nutt, S. L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040973 · Cited by 524 · see citing works
Man, K., Gabriel, S. S., Liao, Y., Gloury, R., Preston, S., Henstridge, D. C., Pellegrini, M., Zehn, D., Berberich‐Siebelt, F., Febbraio, M. A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.11.021 · Cited by 489 · see citing works
Progressive differentiation and selection of the fittest in the immune response
Lanzavecchia, A., & Sallusto, F. (2002) · Nature Reviews Immunology · doi:10.1038/nri959 · Cited by 495 · see citing works
The growing family of interferon regulatory factors
Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480 · see citing works
Taniguchi, T., & Takaoka, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00305-3 · Cited by 476 · see citing works
Falini, B., Fizzotti, M., Pucciarini, A., Bigerna, B., Marafioti, T., Gambacorta, M., Pacini, R., Alunni, C., Natali–Tanci, L., Ugolini, B., et al. (2000) · Blood · doi:10.1182/blood.v95.6.2084 · Cited by 471 · see citing works
Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4
Ochiai, K., Maienschein‐Cline, M., Simonetti, G., Chen, J., Rosenthal, R. L., Brink, R. A., Chong, A. S., Klein, U., Dinner, A. R., Singh, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.009 · Cited by 469 · see citing works
Tamura, T., Tailor, P. B., Yamaoka, K., Kong, H. J., Tsujimura, H., O’Shea, J. J., Singh, H., & Ozato, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2573 · Cited by 422 · see citing works
Negative regulation of Toll-like-receptor signaling by IRF-4
Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., & Honda, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508327102 · Cited by 403 · see citing works
Self-citationMan, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2710 · Cited by 407 · see citing works
Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation
Williams, J. W., Tjota, M. Y., Clay, B. S., Lugt, B. V., Bandukwala, H. S., Hrusch, C. L., Decker, D. C., Blaine, K. M., Fixsen, B. R., Singh, H., et al. (2013) · Nature Communications · doi:10.1038/ncomms3990 · Cited by 402 · see citing works
Colomo, L., López‐Guillermo, A., Perales, M., Rives, S., Martı́nez, A., Bosch, F., Colomer, D., Falini, B., Montserrat, E., & Campo, E. (2002) · Blood · doi:10.1182/blood-2002-04-1286 · Cited by 391 · see citing works
Regulation and functions of Blimp-1 in T and B lymphocytes.
Martins, G., & Calame, K. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090241 · Cited by 416 · see citing works
Lam, L. T., Pickeral, O. K., Peng, A. C., Rosenwald, A., Hurt, E. M., Giltnane, J. M., Averett, L., Zhao, H. G., Davis, R. E., Sathyamoorthy, M., et al. (2001) · Genome biology · doi:10.1186/gb-2001-2-10-research0041 · Cited by 371 · see citing works
Regulatory Mechanisms that Determine the Development and Function of Plasma Cells
Calame, K. L., Lin, K., & Tunyaplin, C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141138 · Cited by 372 · see citing works
Ingraham, C. R., Kinoshita, A., Kondo, S., Yang, B., Sajan, S. A., Trout, K. J., Malik, M., Dunnwald, M., Goudy, S. L., Lovett, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1903 · Cited by 356 · see citing works
Ehrhardt, G. R. A., Hsu, J. T., Gartland, L., Leu, C.-M., Zhang, S., Davis, R. S., & Cooper, M. D. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050879 · Cited by 345 · see citing works
The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production
Yoshida, H., Nishina, H., Takimoto, H., Marengère, L. E. M., Wakeham, A. C., Bouchard, D., Kong, Y., Ohteki, T., Shahinian, A., Bachmann, M. F., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80464-1 · Cited by 339 · see citing works
Self-citationDeregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
Iida, S., Rao, P. H., Butler, M. P., Corradini, P., Boccadoro, M., Klein, B., CHAGANTI, R. S. K., & Dalla‐Favera, R. (1997) · Nature Genetics · doi:10.1038/ng1097-226 · Cited by 335 · see citing works
Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo
Angelin‐Duclos, C., Cattoretti, G., Lin, K., & Calame, K. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5462 · Cited by 337 · see citing works
Rengarajan, J., Mowen, K. A., McBride, K. D., Smith, E. D., Singh, H., & Glimcher, L. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011128 · Cited by 332 · see citing works
Ise, W., Fujii, K., Shiroguchi, K., Ito, A., Kometani, K., Takeda, K., Kawakami, E., Yamashita, K., Suzuki, K., Okada, T., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.027 · Cited by 324 · see citing works
The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
Willis, T. G., & Dyer, M. J. S. (2000) · Blood · doi:10.1182/blood.v96.3.808.015k30_808_822 · Cited by 324 · see citing works
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation
Minnich, M., Tagoh, H., Bönelt, P., Axelsson, E., Fischer, M., Cebolla, B., Tarakhovsky, A., Nutt, S. L., Jaritz, M., & Busslinger, M. (2016) · Nature Immunology · doi:10.1038/ni.3349 · Cited by 318 · see citing works
Roles of the NF- B Pathway in Lymphocyte Development and FunctionPreprint
Gerondakis, S., & Siebenlist, U. K. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000182 · Cited by 321 · see citing works
Critical roles of interferon regulatory factor 4 in CD11b high CD8α – dendritic cell development
Suzuki, S., Honma, K., Matsuyama, T., Suzuki, K. T., Toriyama, K., Akitoyo, I., Yamamoto, K., Suematsu, T., Nakamura, M., Yui, K., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402139101 · Cited by 317 · see citing works
Self-citationSignaling mechanisms, interaction partners, and target genes of STAT6
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Plasma cells: finding new light at the end of B cell development
Calame, K. L. (2001) · Nature Immunology · doi:10.1038/ni1201-1103 · Cited by 308 · see citing works
Hernandez‐Ilizaliturri, F. J., Deeb, G., Zinzani, P. L., Pileri, S. A., Malik, F., Macon, W. R., Goy, A. H., Witzig, T. E., & Czuczman, M. S. (2011) · Cancer · doi:10.1002/cncr.26135 · Cited by 304 · see citing works
Regulation of immunity and oncogenesis by the IRF transcription factor family
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Au, W.-C., Moore, P. A., LaFleur, D. W., TOMBAL, B. F., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29210 · Cited by 295 · see citing works
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Takatsu, K. (2011) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.87.463 · Cited by 298 · see citing works
He, B., Qiao, X., & Cerutti, A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4479 · Cited by 295 · see citing works
The transcriptional programme of antibody class switching involves the repressor Bach2
Muto, A., Tashiro, S., Nakajima, O., Hoshino, H., Takahashi, S., Sakoda, E., Ikebe, D., Yamamoto, M. P., & Igarashi, K. (2004) · Nature · doi:10.1038/nature02596 · Cited by 292 · see citing works
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Aldinger, K. A., Lehmann, O. J., Hudgins, L., Chizhikov, V. V., Bassuk, A. G., Adès, L. C., Krantz, I. D., Dobyns, W. B., & Millen, K. J. (2009) · Nature Genetics · doi:10.1038/ng.422 · Cited by 279 · see citing works
Paun, A., & Pitha, P. M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.01.014 · Cited by 277 · see citing works
Iwakoshi, N. N., Lee, A., & Glimcher, L. H. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00057.x · Cited by 273 · see citing works
IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte developmentPreprint
Lu, R., Medina, K. L., Lancki, D. W., & Singh, H. (2003) · Genes & Development · doi:10.1101/gad.1104803 · Cited by 275 · see citing works
Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3
Schafer, S. L., Lin, R., Moore, P. A., Hiscott, J. B., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2714 · Cited by 266 · see citing works
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression
Kammertoens, T., Friese, C., Arina, A., Idel, C., Briesemeister, D., Rothe, M., Ivanov, A., Szymborska, A., Patone, G., Kunz, S., et al. (2017) · Nature · doi:10.1038/nature22311 · Cited by 271 · see citing works
Plasma cell development and survival
Oracki, S. A., Walker, J. A., Hibbs, M. L., Corcoran, L. M., & Tarlinton, D. M. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00940.x · Cited by 268 · see citing works
Initiation of Plasma-Cell Differentiation Is Independent of the Transcription Factor Blimp-1
Kallies, A., Hasbold, J., Fairfax, K. A., Pridans, C., Emslie, D., McKenzie, B. S., Lew, A. M., Corcoran, L. M., Hodgkin, P. D., Tarlinton, D. M., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.007 · Cited by 266 · see citing works
Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
Lohoff, M. D., Mittrücker, H., Prechtl, S., Bischof, S., Sommer, F. O., Kock, S., Ferrick, D. A., Duncan, G. S., Gessner, A., & Mak, T. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182425099 · Cited by 253 · see citing works
Self-citationTriggering the Interferon Response: The Role of IRF-3 Transcription Factor
Hiscott, J. B., Pitha, P. M., Génin, P., Nguyen, H., Heylbroeck, C., Mamane, Y., Algarté-Génin, M., & Lin, R. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099314360 · Cited by 241 · see citing works
Transcriptional networks in developing and mature B cells
Matthias, P., & Rolink, A. G. (2005) · Nature reviews. Immunology · doi:10.1038/nri1633 · Cited by 238 · see citing works
Biswas, P. S., Gupta, S. K., Chang, E., Li, S., Stirzaker, R. A., Liao, J. K., Bhagat, G., & Pernis, A. B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42856 · Cited by 234 · see citing works
Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4
Cavallari, J. F., Fullerton, M. D., Duggan, B. M., Foley, K. P., Denou, E., Smith, B. K., Desjardins, E. M., Henriksbo, B. D., Kim, K. J., Tuinema, B. R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.021 · Cited by 231 · see citing works
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
Praetorius, C., Grill, C., Stacey, S. N., Metcalf, A. M., Gorkin, D. U., Robinson, K. C., Van Otterloo, E., Kim, R. S. Q., Bergsteinsdottir, K., Ogmundsdottir, M. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.022 · Cited by 228 · see citing works
The genetic network controlling plasma cell differentiation
Nutt, S. L., Taubenheim, N., Hasbold, J., Corcoran, L. M., & Hodgkin, P. D. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.010 · Cited by 224 · see citing works
Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., & Ozato, K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1523 · Cited by 217 · see citing works
IRF4 at the crossroads of effector T‐cell fate decision
Huber, M., & Lohoff, M. D. (2014) · European Journal of Immunology · doi:10.1002/eji.201344279 · Cited by 221 · see citing works
Roles of interferon-regulatory factors in T-helper-cell differentiation
Lohoff, M. D., & Mak, T. W. (2005) · Nature reviews. Immunology · doi:10.1038/nri1552 · Cited by 214 · see citing works
Self-citationGerminal center B and follicular helper T cells: siblings, cousins or just good friends?
Nutt, S. L., & Tarlinton, D. M. (2011) · Nature Immunology · doi:10.1038/ni.2019 · Cited by 215 · see citing works
How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
Glynne, R. J., Akkaraju, S., Healy, J. I., Rayner, J., Goodnow, C. C., & Mack, D. H. (2000) · Nature · doi:10.1038/35001102 · Cited by 210 · see citing works
Brass, A. L., Zhu, A. Q., & Singh, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.977 · Cited by 207 · see citing works
Bollig, N., Brüstle, A., Kellner, K., Ackermann, W., Abass, E. M., Raifer, H., Camara, B., Brendel, C. A., Giel, G., Bothur, E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205834109 · Cited by 200 · see citing works
Self-citationRel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes
Grumont, R. J., & Gerondakis, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1281 · Cited by 198 · see citing works
IRF4 instructs effector Treg differentiation and immune suppression in human cancer
Alvisi, G., Brummelman, J., Puccio, S., Mazza, E. M. C., Tomada, E. P., Losurdo, A., Zanon, V., Peano, C., Colombo, F., Scarpa, A., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130426 · Cited by 195 · see citing works
Falini, B., & Mason, D. Y. (2002) · Blood · doi:10.1182/blood.v99.2.409 · Cited by 193 · see citing works
The Interferon Regulatory Factor Family in Host Defense: Mechanism of Action
Ozato, K., Tailor, P. B., & Kubota, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700003200 · Cited by 191 · see citing works
IRF4: Immunity. Malignancy! Therapy?
Shaffer, A. L., Emre, N. C. T., Romesser, P. B., & Staudt, L. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1845 · Cited by 189 · see citing works
Lee, C. H., Melchers, M., Wang, H., Torrey, T. A., Slota, R., Qi, C., Kim, J. Y., Lugar, P., Kong, H. J., Farrington, L. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051450 · Cited by 186 · see citing works
Chen, Q., Yang, W., Gupta, S. K., Biswas, P. S., Smith, P., Bhagat, G., & Pernis, A. B. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.011 · Cited by 185 · see citing works
Differentiation of memory B and T cells
Kalia, V., Sarkar, S., Gourley, T. S., Rouse, B. T., & Ahmed, R. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.020 · Cited by 184 · see citing works
Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells
Tamura, T., & Ozato, K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452755 · Cited by 183 · see citing works
Lopez‐Girona, A., Heintel, D., Zhang, L., Mendy, D., Gaidarova, S., Brady, H. A., Bartlett, J. B., Schafer, P. H., Schreder, M., Bolomsky, A., et al. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08689.x · Cited by 183 · see citing works
Analysis of MUM1/IRF4 Protein Expression Using Tissue Microarrays and Immunohistochemistry
Natkunam, Y., Warnke, R. A., Montgomery, K. D., Falini, B., & van de Rijn, M. (2001) · Modern Pathology · doi:10.1038/modpathol.3880373 · Cited by 175 · see citing works
The Multiple Roles of Interferon Regulatory Factor family in Health and Disease
Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178 · see citing works
MUM1/IRF4 expression as a frequent event in mature lymphoid malignancies
Tsuboi, K., Iida, S., Inagaki, H., Kato, M., Hayami, Y., Hanamura, I., Miura, K., Harada, S., Kikuchi, M., Komatsu, H., et al. (2000) · Leukemia · doi:10.1038/sj.leu.2401696 · Cited by 177 · see citing works
Regulation of IL4 gene expression by T cells and therapeutic perspectives
Li‐Weber, M., & Krammer, P. H. (2003) · Nature reviews. Immunology · doi:10.1038/nri1128 · Cited by 171 · see citing works
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
Kallies, A., Carotta, S., Huntington, N. D., Bernard, N. J., Tarlinton, D. M., Smyth, M. J., & Nutt, S. L. (2010) · Blood · doi:10.1182/blood-2010-08-303123 · Cited by 172 · see citing works
Achuthan, A. A., Cook, A. D., Lee, M.-C., Saleh, R., Khiew, H. W., Chang, M. W., Louis, C., Fleetwood, A. J., Lacey, D. C., Christensen, A. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87828 · Cited by 172 · see citing works
IRF4 Promotes Cutaneous Dendritic Cell Migration to Lymph Nodes during Homeostasis and Inflammation
Bajaña, S., Roach, K., Turner, S., Paul, J. A., & Kovats, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102613 · Cited by 171 · see citing works
Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
Günthner, R., & Anders, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/731023 · Cited by 164 · see citing works
- Authors
- Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W.
- Affiliations
- University of Toronto (CA)
- Nagasaki University (JP)
- B. Patterson, Department of Oncologic Pathology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2C1, Canada.
- Venue
- Science
- Published
- 1997-01-24
- Volume
- 275
- Issue
- 5299
- Pages
- 540-543
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022687427
- Cited by
- 583
- References
- 21
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 23 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 20 · 2016: 15 · 2015: 18 · 2014: 25 · 2013: 32 · 2012: 20
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- IRF4, transcription factors, B cells, T cells, lymphocyte homeostasis, lymphadenopathy, antibody deficiency, antibody response, cytotoxic T lymphocytes, antitumor immunity
- MeSH terms
- Lymphadenopathy, Interferon Regulatory Factor-4, Animals, Antibody Formation, B-Lymphocytes, Cell Differentiation, Cells, Cultured, Homeostasis, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Mice, SCID, Mice, Knockout, Cell Proliferation, Interferon Regulatory Factors, Mice
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