The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Role of CXCR4 in Maintaining Peripheral B Cell Compartments and Humoral Immunity
Open accessAbstract
The chemokine receptor CXCR4 is expressed in B cells at multiple stages of their development. CXCR4 function in humoral immunity has not been fully investigated. We have generated gene-targeted mice in which CXCR4 can be selectively inactivated in B cells and have shown that it is required for retention of B cell precursors in the bone marrow. CXCR4-deficient B cell precursors that migrated prematurely became localized in splenic follicles despite their unresponsiveness to CXCL13. Concomitantly, mature B cell populations were reduced in the splenic marginal zone and primary follicles, and in the peritoneal cavity in the mutant animals, as were T-independent antibody responses. In addition, aberrant B cell follicles formed ectopically in intestinal lamina propria around Peyer's patches. These findings establish an important role for CXCR4 in regulating homeostasis of B cell compartmentalization and humoral immunity.
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Citations
Cites
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Cited by
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Human mesenchymal stem cells modulate B-cell functions
Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767
Victora, G. D., Schwickert, T. A., Fooksman, D. R., Kamphorst, A. O., Meyer-Hermann, M., Dustin, M. L., & Nussenzweig, M. C. (2010) · Cell · doi:10.1016/j.cell.2010.10.032 · Cited by 1,238
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
Ding, B.-S., Cao, Z., Lis, R., Nolan, D. J., Guo, P., Simons, M., Penfold, M. E., Shido, K., Rabbany, S. Y., & Rafii, S. (2014) · Nature · doi:10.1038/nature12681 · Cited by 626
B-cell biology and development
Pieper, K., Grimbacher, B., & Eibel, H. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.01.046 · Cited by 615
Metadata
- Authors
- Nie, Y., Waite, J., Brewer, F., Sunshine, M.-J., Littman, D. R., & Zou, Y.-R.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-11-01
- Volume
- 200
- Issue
- 9
- Pages
- 1145-1156
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2100386815
- Cited by
- 397
- References
- 1
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nie, Y., Waite, J., Brewer, F., Sunshine, M.-J., Littman, D. R., & Zou, Y.-R. (2004). The Role of CXCR4 in Maintaining Peripheral B Cell Compartments and Humoral Immunity. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20041185
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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