The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells
Open accessAbstract
The mechanisms of homing of endothelial progenitor cells (EPCs) to sites of ischemia are unclear. Here, we demonstrate that ex vivo–expanded EPCs as well as murine hematopoietic Sca-1+/Lin− progenitor cells express β2-integrins, which mediate the adhesion of EPCs to endothelial cell monolayers and their chemokine-induced transendothelial migration in vitro. In a murine model of hind limb ischemia, Sca-1+/Lin− hematopoietic progenitor cells from β2-integrin–deficient mice are less capable of homing to sites of ischemia and of improving neovascularization. Preactivation of the β2-integrins expressed on EPCs by activating antibodies augments the EPC-induced neovascularization in vivo. These results provide evidence for a novel function of β2-integrins in postnatal vasculogenesis.
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Self-citationTransplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
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Unchain my heart: the scientific foundations of cardiac repair
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The clinical significance of endothelial dysfunction
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Metadata
- Authors
- Chavakis, E., Aicher, A., Heeschen, C., Sasaki, K.-I., Kaiser, R., El Makhfi, N., Urbich, C., Peters, T., Scharffetter-Kochanek, K., Zeiher, A. M., Chavakis, T., & Dimmeler, S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-12-28
- Volume
- 201
- Issue
- 1
- Pages
- 63-72
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2129718198
- Cited by
- 304
- References
- 50
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chavakis, E., Aicher, A., Heeschen, C., Sasaki, K.-I., Kaiser, R., El Makhfi, N., Urbich, C., Peters, T., Scharffetter-Kochanek, K., Zeiher, A. M., Chavakis, T., & Dimmeler, S. (2005). Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20041402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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