The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines
Open accessAbstract
The large size of poxvirus genomes has stymied attempts to identify determinants recognized by CD8+ T cells and greatly impeded development of mouse smallpox vaccination models. Here, we use a vaccinia virus (VACV) expression library containing each of the predicted 258 open reading frames to identify five peptide determinants that account for approximately half of the VACV-specific CD8+ T cell response in C57BL/6 mice. We show that the primary immunodominance hierarchy is greatly affected by the route of VACV infection and the poxvirus strain used. Modified vaccinia virus ankara (MVA), a candidate replacement smallpox vaccine, failed to induce responses to two of the defined determinants. This could not be predicted by genomic comparison of viruses and is not due strictly to limited MVA replication in mice. Several determinants are immunogenic in cowpox and ectromelia (mousepox) virus infections, and immunization with the immunodominant determinant provided significant protection against lethal mousepox. These findings have important implications for understanding poxvirus immunity in animal models and bench-marking immune responses to poxvirus vaccines in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,566
(1988) · World Health Organization eBooks · Cited by 1,574
IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES
Yewdell, J. W., & Bennink, J. R. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.51 · Cited by 944
Self-citationCloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.
Shen, Z., Reznikoff, G., Dranoff, G., & Rock, K. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2723 · Cited by 846
Chakrabarti, S., Brechling, K., & Moss, B. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.12.3403 · Cited by 777
Seet, B. T., Johnston, J. B., Brunetti, C. R., Barrett, J. W., Everett, H., Cameron, C., Sypula, J., Nazarian, S. H., Lucas, A., & McFadden, G. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141049 · Cited by 666
Vremec, D., Zorbas, M., Scollay, R., Saunders, D. J., Ardavin, C. F., Wu, L., & Shortman, K. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.47 · Cited by 625
Nonreplicating vaccinia vector efficiently expresses recombinant genes.
Sutter, G., & Moss, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10847 · Cited by 600
Antoine, G., Scheiflinger, F., Dorner, F., & Falkner, F. G. (1998) · Virology · doi:10.1006/viro.1998.9123 · Cited by 507
Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox
Earl, P. L., Americo, J. L., Wyatt, L. S., Eller, L. A., Whitbeck, J. C., Cohen, G. H., Eisenberg, R. J., Hartmann, C. J., Jackson, D. L., Kulesh, D. A., et al. (2004) · Nature · doi:10.1038/nature02331 · Cited by 455
Cited by
Sette, A., Moutaftsi, M., Moyron-Quiroz, J., McCausland, M. M., Davies, D. H., Johnston, R. J., Peters, B., Rafii-El-Idrissi Benhnia, M., Hoffmann, J., Su, H.-P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.018 · Cited by 168
Self-citationSosinowski, T., White, J. T., Cross, E. W., Haluszczak, C., Marrack, P., Gapin, L., & Kedl, R. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203149 · Cited by 149
Larena, M., Regner, M., & Lobigs, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044834 · Cited by 38
Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production
Daszkiewicz, L., Vázquez-Mateo, C., Rackov, G., Ballesteros-Tato, A., Weber, K., Madrigal-Avilés, A., Di Pilato, M., Fotedar, A., Fotedar, R., Flores, J. M., et al. (2015) · Scientific Reports · doi:10.1038/srep07691 · Cited by 26
Metadata
- Authors
- Tscharke, D. C., Karupiah, G., Zhou, J., Palmore, T., Irvine, K. R., Haeryfar, S. M. M., Williams, S., Sidney, J., Sette, A., Bennink, J. R., & Yewdell, J. W.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-12-28
- Volume
- 201
- Issue
- 1
- Pages
- 95-104
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2152245700
- Cited by
- 299
- References
- 33
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. https://app.cochat.ai/papers/10.1084/jem.20041912
- The paper
- Tscharke, D. C., Karupiah, G., Zhou, J., Palmore, T., Irvine, K. R., Haeryfar, S. M. M., Williams, S., Sidney, J., Sette, A., Bennink, J. R., & Yewdell, J. W. (2005). Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20041912
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
