The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Decay-accelerating factor modulates induction of T cell immunity
Open accessAbstract
Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells and thereby prevents complement activation on their surfaces. We demonstrate that during primary T cell activation, the absence of Daf on antigen-presenting cells (APCs) and on T cells enhances T cell proliferation and augments the induced frequency of effector cells. The effect is factor D- and, at least in part, C5-dependent, indicating that local alternative pathway activation is essential. We show that cognate T cell–APC interactions are accompanied by rapid production of alternative pathway components and down-regulation of Daf expression. The findings argue that local alternative pathway activation and surface Daf protein function respectively as a costimulator and a negative modulator of T cell immunity and explain previously reported observations linking complement to T cell function. The results could have broad therapeutic implications for disorders in which T cell immunity is important.
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Cites
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Medof, M. E., Kinoshita, T., & Nussenzweig, V (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.5.1558 · Cited by 561
Self-citationLocal synthesis of complement component C3 regulates acute renal transplant rejection
Pratt, J. R., Basheer, S. A., & Sacks, S. H. (2002) · Nature Medicine · doi:10.1038/nm0602-582 · Cited by 534
Kopf, M., Abel, B., Gallimore, A., Carroll, M., & Bachmann, M. F. (2002) · Nature Medicine · doi:10.1038/nm0402-373 · Cited by 311
γ chain required for naïve CD4+ T cell survival but not for antigen proliferation
Lantz, O., Grandjean, I., Matzinger, P., & Di Santo, J. P. (2000) · Nature Immunology · doi:10.1038/76917 · Cited by 303
GPI-microdomains: a role in signalling via immunoreceptors
Hořejšı́, V., Drbal, K., Cebecauer, M., Černý, J., Brdička, T., Angelisová, P., & Stockinger, H. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01489-9 · Cited by 269
Activation changes the spectrum but not the diversity of genes expressed by T cells
Teague, T. K., Hildeman, D., Kedl, R. M., Mitchell, T., Rees, W., Schaefer, B. C., Bender, J., Kappler, J., & Marrack, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12691 · Cited by 223
Cell‐surface engineering with GPI‐anchored proteins
Medof, M. E., Nagarajain, S., & Tykocinski, M. L. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.5.8621057 · Cited by 209
Self-citationInfluence of C3 Deficiency on Atherosclerosis
Buono, C., Come, C. E., Witztum, J. L., Maguire, G. F., Connelly, P. W., Carroll, M., & Lichtman, A. H. (2002) · Circulation · doi:10.1161/01.cir.0000019584.04929.83 · Cited by 165
Simpson, E., Scott, D. M., & Chandler, P. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.39 · Cited by 156
Cited by
Complement and its role in innate and adaptive immune responses
Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932
Complement System Part II: Role in Immunity
Merle, N. S., Noe, R., Halbwachs-Mecarelli, L., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00257 · Cited by 1,051
The role of the anaphylatoxins in health and disease
Klos, A., Tenner, A. J., Johswich, K.-O., Ager, R. R., Reis, E. S., & Köhl, J. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.04.027 · Cited by 730
Strainic, M. G., Liu, J., Huang, D., An, F., Lalli, P. N., Muqim, N., Shapiro, V. S., Dubyak, G. R., Heeger, P. S., & Medof, M. E. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.001 · Cited by 580
Self-citationGirardi, G., Yarilin, D., Thurman, J. M., Holers, V. M., & Salmon, J. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061022 · Cited by 508
Metadata
- Authors
- Heeger, P. S., Lalli, P. N., Lin, F., Valujskikh, A., Liu, J., Muqim, N., Xu, Y., & Medof, M. E.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-05-09
- Volume
- 201
- Issue
- 10
- Pages
- 1523-1530
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2139620102
- Cited by
- 286
- References
- 22
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Heeger, P. S., Lalli, P. N., Lin, F., Valujskikh, A., Liu, J., Muqim, N., Xu, Y., & Medof, M. E. (2005). Decay-accelerating factor modulates induction of T cell immunity. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20041967
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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