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Cited by 306

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Cellular immune selection with hepatitis C virus persistence in humans

Open access
Cox, Andrea L., Mosbruger, Timothy, Mao, Qing, Liu, Zhi, Wang, Xiao-Hong, Yang, Hung-Chih, Sidney, John, Sette, Alessandro, Pardoll, Drew, Thomas, David L., Ray, Stuart C.·2005·The Journal of Experimental Medicine
DOI 10.1084/jem.20050121
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Abstract

Hepatitis C virus (HCV) infection frequently persists despite substantial virus-specific cellular immune responses. To determine if immunologically driven sequence variation occurs with HCV persistence, we coordinately analyzed sequence evolution and CD8+ T cell responses to epitopes covering the entire HCV polyprotein in subjects who were followed prospectively from before infection to beyond the first year. There were no substitutions in T cell epitopes for a year after infection in a subject who cleared viremia. In contrast, in subjects with persistent viremia and detectable T cell responses, we observed substitutions in 69% of T cell epitopes, and every subject had a substitution in at least one epitope. In addition, amino acid substitutions occurred 13-fold more often within than outside T cell epitopes (P < 0.001, range 5–38). T lymphocyte recognition of 8 of 10 mutant peptides was markedly reduced compared with the initial sequence, indicating viral escape. Of 16 nonenvelope substitutions that occurred outside of known T cell epitopes, 8 represented conversion to consensus (P = 0.015). These findings reveal two distinct mechanisms of sequence evolution involved in HCV persistence: viral escape from CD8+ T cell responses and optimization of replicative capacity.

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Metadata

Authors
Cox, A. L., Mosbruger, T., Mao, Q., Liu, Z., Wang, X.-H., Yang, H.-C., Sidney, J., Sette, A., Pardoll, D., Thomas, D. L., & Ray, S. C.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2005-06-06
Volume
201
Issue
11
Pages
1741-1752
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20050121
OpenAlex
W2103802132
Cited by
306
References
58
FWCI
17.77
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Cellular immune selection with hepatitis C virus persistence in humans. https://app.cochat.ai/papers/10.1084/jem.20050121
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Cox, A. L., Mosbruger, T., Mao, Q., Liu, Z., Wang, X.-H., Yang, H.-C., Sidney, J., Sette, A., Pardoll, D., Thomas, D. L., & Ray, S. C. (2005). Cellular immune selection with hepatitis C virus persistence in humans. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20050121

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