The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Flying Under the Radar: The Immunobiology of Hepatitis C
Abstract
The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent infection in more than two-thirds of those who contract it. Its success is related to its abilities to blunt innate antiviral pathways and to evade adaptive immune responses. These two themes may be related. We propose that HCV takes advantage of the impaired innate response to delay the organization of an effective adaptive immune attack. The tolerogenic liver environment may provide cover, prolonging this delay. HCV's error-prone replication strategy permits rapid evolution under immune pressure. Persistent high levels of viral antigens may contribute to immune exhaustion. Finally, the virus may benefit from the efficient enlistment of memory T and B cells in the pursuit of a moving target.
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Cites
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Cited by
Immune responses and immunopathology in acute and chronic viral hepatitis
Shin, E.-C., Sung, P. S., & Park, S.-H. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.69 · Cited by 365
Distinct plasma immune signatures in ME/CFS are present early in the course of illness
Hornig, M., Montoya, J. G., Klimas, N. G., Levine, S., Felsenstein, D., Bateman, L., Peterson, D. L., Gottschalk, C. G., Schultz, A. F., Che, X., et al. (2015) · Science Advances · doi:10.1126/sciadv.1400121 · Cited by 263
The Interferon Inducible Gene: Viperin
Fitzgerald, K. A. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0127 · Cited by 163
Mechanisms linking pathogens-associated inflammation and cancer
Porta, C., Riboldi, E., & Sica, A. (2011) · Cancer Letters · doi:10.1016/j.canlet.2010.10.012 · Cited by 119
Vaccines to Prevent Infections by Oncoviruses
Schiller, J. T., & Lowy, D. R. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134019 · Cited by 101
Metadata
- Authors
- Dustin, L. B., & Rice, C. M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2007-04-01
- Volume
- 25
- Issue
- 1
- Pages
- 71-99
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2096779842
- Cited by
- 313
- References
- 152
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dustin, L. B., & Rice, C. M. (2007). Flying Under the Radar: The Immunobiology of Hepatitis C. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.25.022106.141602
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
