The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A role for sex chromosome complement in the female bias in autoimmune disease
Open accessAbstract
Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.
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De Vries, G. J., Rissman, E. F., Simerly, R. B., Yang, L.-Y., Scordalakes, E. M., Auger, C. J., Swain, A., Lovell-Badge, R., Burgoyne, P. S., & Arnold, A. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09005.2002 · Cited by 509
Self-citationSex differences in experimental autoimmune encephalomyelitis in multiple murine strains
Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.018 · Cited by 152
Okuda, Y., Okuda, M., & Bernard, C. C. A. (2002) · Immunology Letters · doi:10.1016/s0165-2478(01)00339-x · Cited by 77
Cited by
Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370
The X-files in immunity: sex-based differences predispose immune responses
Fish, E. N. (2008) · Nature Reviews Immunology · doi:10.1038/nri2394 · Cited by 1,162
Rubtsov, A. V., Rubtsova, K., Fischer, A., Meehan, R. T., Gillis, J. Z., Kappler, J. W., & Marrack, P. (2011) · Blood · doi:10.1182/blood-2011-01-331462 · Cited by 808
Reframing sexual differentiation of the brain
McCarthy, M. M., & Arnold, A. P. (2011) · Nature Neuroscience · doi:10.1038/nn.2834 · Cited by 728
Self-citationArnold, A. P. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.011 · Cited by 625
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Metadata
- Authors
- Smith-Bouvier, D. L., Divekar, A. A., Sasidhar, M., Du, S., Tiwari-Woodruff, S. K., King, J. K., Arnold, A. P., Singh, R. R., & Voskuhl, R. R.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2008-04-28
- Volume
- 205
- Issue
- 5
- Pages
- 1099-1108
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2063819412
- Cited by
- 397
- References
- 3
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Smith-Bouvier, D. L., Divekar, A. A., Sasidhar, M., Du, S., Tiwari-Woodruff, S. K., King, J. K., Arnold, A. P., Singh, R. R., & Voskuhl, R. R. (2008). A role for sex chromosome complement in the female bias in autoimmune disease. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20070850
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