CoChat
Sign Up
Cited by 152Multiple Sclerosis Research StudiesSystemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Papenfuss, Tracey L., Rogers, Connie J., Gienapp, Ingrid, Yurrita, Maria, McClain, Melanie, Damico, Nicole, Valo, Janie, Song, Fei +1 more·2004·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2004.01.018
Open this paper in CoChat — free account

Abstract

Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.

Integrity signals

Registry

Crossref · 10.1016/j.jneuroim.2004.01.018

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Female SJL and ASW mice have more severe EAE than males when induced by active immunization.

    “A comprehensive comparison of EAE clinical disease scores in several mouse strains revealed that female SJL and ASW have more severe EAE than males when induced by active immunization (44).”

    From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]

  • Several strains of rodents display gender differences in disease incidence and severity in experimental autoimmune encephalomyelitis (EAE).

    “In the experimental autoimmune encephalomyelitis (EAE) animal model for demyelinating disease, several strains of rodents display gender differences in disease incidence and severity 3, 4, 44, 53.”

    From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]

  • In the EAE model, female SJL mice are both more susceptible to disease induction and exhibit more severe neurological deficits.

    “Nevertheless, these findings of gender differences are in contrast to those in the EAE model, in which female SJL mice are both more susceptible to disease induction and exhibit more severe neurological deficits 3, 44, 53.”

    From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]

  • Male and female C57Bl/6 mice present with similar disease courses, but females often have increased infiltration of immune cells to the spinal cord accompanied by increased demyelination compared to males.

    “Interestingly, it has been shown that male and female mice present with similar disease courses, but that females often have increased infiltration of immune cells to the spinal cord accompanied by increased demyelination compared to males [152, 153].”

    From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]

  • The A.SW-EAE model represents both PPMS and SPMS, with disease courses that include both PMS phenotypes.

    “The A.SW-EAE model offers a unique representation of both PPMS and SPMS, with disease courses that include both PMS phenotypes.”

    From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C.
Affiliations
The Ohio State University (US)
Corresponding author
Papenfuss, Tracey L.
ORCID
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2004-05
Volume
150
Issue
1-2
Pages
59-69
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/j.jneuroim.2004.01.018
OpenAlex
W2048700200
Cited by
152
References
50
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 4 · 2012: 4
FWCI
3.82
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Multiple Sclerosis Society
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI043376, AI43376)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
experimental autoimmune encephalomyelitis, sex differences, multiple sclerosis, mouse strains, myelin proteolipid protein, myelin oligodendrocyte glycoprotein, SJL mice, NZW mice, disease severity, autoimmune disease susceptibility
MeSH terms
Amino Acid Sequence, Animals, Castration, Encephalomyelitis, Autoimmune, Experimental, Female, Male, Mice, Inbred C57BL, Mice, Inbred NZB, Mice, Inbred Strains, Molecular Sequence Data, Ovariectomy, Severity of Illness Index, Sex Characteristics, Species Specificity, Incidence, Mice, Inbred NOD, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review