ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

Cited by (250)

Items 201–250 of 250

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7. 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice
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8. Early Emergence of Adaptive Mechanisms Sustaining Ig Production: Application to Antibody Therapy
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9. Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis
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10. Molecular Mechanisms Underlying Oxytosis
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11. Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats
    Yukako Shimotsuma, Miyuu Tanaka, Takeshi Izawa, Jyoji Yamate, Mitsuru Kuwamura · 2016 · PLoS ONE
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14. HACE1 exerts a neuroprotective role against oxidative stress in cerebral ischemia-reperfusion injury by activating the PI3K/AKT/Nrf2 pathway.
    Xinyue Zhang, Xiao Wang, Le Yin, Dan Wang, Hong Jiao, Xiaodan Liu, Jiao-Lin Zheng · 2024 · Neuroscience
15. Gene Expression Profiling to Unfolded Proteins Response as a Risk Modulator of Patients with Rheumatoid Arthritis
    Aleksandra Kucharska-Lusina, Maciej Skrzypek, Aleksandra Binda, Ireneusz Majsterek · 2024 · International Journal of Molecular Sciences
16. Reduction in activating transcription factor 4 promotes carbon tetrachloride and lipopolysaccharide/D‑galactosamine‑mediated liver injury in mice.
    Xiaofang Zhao, Hong Zhou, Ying Cheng, Wenjing Yu, Guosong Luo, Chun-Yan Duan, Fu-Li Yao, Bin Xiao, Chun-Hong Feng, Xian-Ming Xia et al. · 2018 · Molecular Medicine Reports
17. A novel synthetic chalcone derivative promotes caspase-dependent apoptosis through ROS generation and activation of the UPR in MH7A cells
    Jin-Hyun Kim, Y. Jeon, Jaewook Cho, Jong-Il Shin, C. Baek, Y. Lim, D. Koh, S. Shin, Young-Han Lee, Kyungho Lee · 2015 · Genes & Genomics
18. Fucoxanthin protects placenta-derived human mesenchymal stem cells against oxidative stress-induced apoptosis by modulating genes involved in DNA damage repair, ER stress response, p53-induced apoptosis
    Gunticha Suwanmanee, P. Kheolamai, C. Tantrawatpan, Danielle Grimes, I. V. Matei, Luminita Paraoan, Sirikul Manochantr · 2025 · Stem cell research & therapeutics
19. Recent Advances and Therapeutic Implications of 2-Oxoglutarate-Dependent Dioxygenases in Ischemic Stroke
    Jian Ming Xie, Zhijun Zhang · 2023 · Molecular Neurobiology
20. Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
    Wenlong Xia, Laura R. Morcom, Zhaoyang Xu, I-Ling Lu, Qing Wang, Kimberly K. Hoi, Mingming Wei, Keying Zhu, Gregory E. Jordan, Xiao-Yan Tang et al. · 2026 · Nature
21. CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions
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22. Tetramethylpyrazine mitigates ER-stress-driven ATF4/CHOP apoptosis to protect dopaminergic neurons in cellular and MPTP models of Parkinson's disease.
    Sha Zhan, Shao Wen, Li-Li Wu, Xinyue Zhang, Jiawen Liu, Guijuan Zhang, Hongjie Liu · 2026 · Neuropharmacology
23. The dual role of activating transcription factor 4: from cellular stress sentinel to cardiovascular disease intervention
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24. Alcohol disrupts neural differentiation through endoplasmic reticulum stress and PERK pathway activation
    Zuohui Zhang, Wen Wen, Hong Lin, Di Hu, Hui Li, Jia Luo · 2025 · Neurochemistry International
25. Decoding shared molecular mechanisms of SARS-CoV-2 and HCoV-OC43 in COVID-19 neurological manifestations: a systems biology approach
    Maryam Mozafar, Seyed Amir Mirmotalebisohi, Marzieh Sameni, Zeinab Dehghan, Hassan Zohrevand, Zargham Sepehrizadeh, Mohammad Ali Faramarzi, Ahmad Reza Shahverdi, Hakimeh Zali · 2025 · Gene Reports
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28. ATF4 regulates neuronal death in models of Parkinson’s Disease
    Matthew D. Demmings, Gillian N. Petroff, Heather E Tarnowski-Garner, S. Cregan · 2019 · bioRxiv
29. Disruption of Redox Homeostasis by Enzymatic Activation of a Triakylphosphine Probe in Mitochondria
    J. Nguyen, Alina Tirla, Pablo Rivera‐Fuentes · 2019
30. Research Progress of Fluorescent Probes for Cysteine Targeting Cellular Organelles
    Feiran Liu, Jing Jing, Xiaoling Zhang · 2023 · Chinese Journal of Organic Chemistry
31. ATF4 Activation Promotes All-trans-Retinal-Driven Retinopathies in Mice
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32. YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer
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34. Targeting ATF3-mediated asparagine biosynthesis reverses acquired resistance to KRASG12C inhibitors
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    Zerrin Yıldız Çavdar, Ahmet Sertbaş, T. Ensari, Muberra N. Akcaman · 2026 · GAZI UNIVERSITY JOURNAL OF SCIENCE
36. Atf4a Regulates Mitochondrial Homeostasis Through Parkin‐Mediated Mitophagy to Enhance Hypoxia Tolerance in Zebrafish (Danio rerio)
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    Peng-fei Zhu, Zhaoru Lyu, Qingsong Wang, S Li, Xuan Wang, Ailin Luo · 2026 · Pharmacological Research
38. Suppression rather than activation of the integrated stress response (GCN2–ATF4) pathway extends lifespan in the fly
    Miriam S Götz, Dan J. Hayman, Gracie Adams, Fumiaki Obata, Mirre J. P. Simons · 2026 · Proceedings of the National Academy of Sciences
39. Neuromuscular junction innervation and motor function are preserved by restoring muscarinic signaling in perisynaptic glia in ALS
    E. Tremblay, Danielle Arbour, Joanne Vallée, R. Piovesana, G. Vallières, Emine Mechichi, R. Robitaille · 2026 · iScience
40. Wnt Signaling Downregulation Mediates T Cell Apoptosis Following OKT3‐Induced T Cell Activation in Preclinical Models
    Myeongjin Choi, D. Park, Darren Lee, Chang-Hoon Choi, Minseong Jo, S. Y. Jeong, Seung-Ye-On Lim, Daeui Park, Kyoung-Sik Moon · 2026 · The FASEB Journal
41. Temporal Dynamics of Endothelium After Radiation Injury Reveal a Transient Pro-Angiogenic Capillary Subpopulation Associated with Skin Repair
    Xuejiao Ren, Yating Cai, Chengming Gao, Yifei Qiu, Xia Wang, Huiyang Song, Yansheng Zhu, Xiaoqi Zhou, Jianhao Li, Gangqiao Zhou et al. · 2026 · International Journal of Molecular Sciences
42. Ironing out mechanisms of ferroptotic death to tailor new stroke therapies
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43. Expression and distribution of tribbles pseudokinase 3 in oxidative stress-mediated acute liver and kidney injury models
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44. Identification of Hub Genes for Dexmedetomidine Alleviation of Limb Ischemia-Reperfusion-Induced Lung Injury in Rats by Transcriptomic
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45. Chemogenetic neuronal silencing decouples c‐Jun activation from cell death in the temporal cortex
    Caleb A. Wood, Preethi Somasundaram, Jacob M. Dundee, Melissa A. Rudy, Trent A. Watkins, Joanna L. Jankowsky · 2024 · European Journal of Neuroscience
46. Nongenomic effect of aldosterone on angiotensin II type 1 receptor dimerization in human renal proximal tubular cells: Implications for endoplasmic reticulum stress
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49. Ischemia Regulated Transcription Factors: Hypoxia Inducible Factor 1 and Activating Transcription Factor 4
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50. Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
    Z. Galehdar · 2013